Reactome | Resolution of sister chromatids

Resolution of sister chromatids

Stable Identifier

R-HSA-2467794

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

chromosome, cytosol

ReviewStatus

5/5

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Cohesin complexes dissociate from chromosomal arms in prometaphase, leading to sister chromatid resolution. Sister chromatid resolution involves separation of sister chromosomal arms while cohesion at sister centromeres persists (Losada et al. 1998, Hauf et al. 2001, Hauf et al. 2005). Cohesin and CDCA5 (Sororin) simultaneously dissociate from chromosomal arms in prometaphase (Nishiyama et al. 2010, Zhang et al. 2011). This process, triggered by CDK1-mediated phosphorylation of CDCA5 (Dreier et al. 2011, Zhang et al. 2011) and PLK1-mediated phosphorylation of the STAG2 cohesin subunit (Hauf et al. 2005), is controlled by WAPAL (Gandhi et al. 2006, Kueng et al. 2006, Shintomi and Hirano 2009). WAPAL controls cohesion of sister chromatids likely through competing with CDCA5 for binding to cohesin-associated PDS5 (PDS5A and PDS5B) (Nishiyama et al. 2010). While the interaction of WAPAL with PDS5 depends on CDCA5 (Nishiyama et al. 2010), WAPAL maintains its association with cohesin through interaction with cohesin subunits (Kueng et al. 2006, Shintomi and Hirano 2009).

Literature References

PubMed ID	Title	Journal	Year
17113138	Wapl controls the dynamic association of cohesin with chromatin Kueng, S, Hegemann, B, Peters, BH, Lipp, JJ, Schleiffer, A, Mechtler, K, Peters, JM	Cell	2006
11509732	Cohesin cleavage by separase required for anaphase and cytokinesis in human cells Hauf, S, Waizenegger, IC, Peters, JM	Science	2001
9649503	Identification of Xenopus SMC protein complexes required for sister chromatid cohesion Losada, A, Hirano, M, Hirano, T	Genes Dev.	1998
19696148	Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 Shintomi, K, Hirano, T	Genes Dev.	2009
16682347	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression Watrin, E, Schleiffer, A, Tanaka, K, Eisenhaber, F, Nasmyth, K, Peters, JM	Curr. Biol.	2006
21878504	Regulation of sororin by Cdk1-mediated phosphorylation Dreier, MR, Bekier, ME, Taylor, WR	J. Cell. Sci.	2011
21111234	Sororin mediates sister chromatid cohesion by antagonizing Wapl Nishiyama, T, Ladurner, R, Schmitz, J, Kreidl, E, Schleiffer, A, Bhaskara, V, Bando, M, Shirahige, K, Hyman, AA, Mechtler, K, Peters, JM	Cell	2010
17112726	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase Gandhi, R, Gillespie, PJ, Hirano, T	Curr. Biol.	2006
21987589	Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion Zhang, N, Panigrahi, AK, Mao, Q, Pati, D	J. Biol. Chem.	2011
15737063	Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 Hauf, S, Roitinger, E, Koch, B, Dittrich, CM, Mechtler, K, Peters, JM	PLoS Biol	2005