Up to anaphase onset, ESPL1 (separase i.e. separin) forms a complex with PTTG1 (pituitary tumor-transforming gene 1) i.e. securin. PTTG1 sequesters ESPL1 and block its catalytic site, preventing it from cleaving centromeric cohesin and causing premature separation of sister chromatids (Zou et al. 1999, Waizenegger et al. 2001, Waizenegger et al. 2002). PTTG1 is overexpressed in cancer and acts as an oncogene (Zhang et al. 1999). Regulation of PTTG1 cellular level is important for chromosomal stability in human cells (Jallepalli et al. 2001).
Horwitz, GA, Prezant, TR, Zhang, X, Bronstein, MD, Valentini, A, Nakashima, M, Melmed, S
Waizenegger, IC, Meinke, A, Hauf, S, Peters, JM
Speicher, MR, Jallepalli, PV, Vogelstein, B, Waizenegger, IC, Bunz, F, Lengauer, C, Kinzler, KW, Peters, JM, Langer, S
Peters, JM, Waizenegger, I, Wernic, D, Giménez-Abián, JF
McGarry, TJ, Kirschner, MW, Bernal, T, Zou, H
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