PTTG1 (Securin) sequesters ESPL1 (Separase)

Stable Identifier
R-HSA-2467798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Securin sequesters Separase
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Up to anaphase onset, ESPL1 (separase i.e. separin) forms a complex with PTTG1 (pituitary tumor-transforming gene 1) i.e. securin. PTTG1 sequesters ESPL1 and block its catalytic site, preventing it from cleaving centromeric cohesin and causing premature separation of sister chromatids (Zou et al. 1999, Waizenegger et al. 2001, Waizenegger et al. 2002). PTTG1 is overexpressed in cancer and acts as an oncogene (Zhang et al. 1999). Regulation of PTTG1 cellular level is important for chromosomal stability in human cells (Jallepalli et al. 2001).

Literature References
PubMed ID Title Journal Year
11081627 Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

Waizenegger, IC, Hauf, S, Meinke, A, Peters, JM

Cell 2000
9892021 Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)

Zhang, X, Horwitz, GA, Prezant, TR, Valentini, A, Nakashima, M, Bronstein, MD, Melmed, S

Mol. Endocrinol. 1999
11371342 Securin is required for chromosomal stability in human cells

Jallepalli, PV, Waizenegger, IC, Bunz, F, Langer, S, Speicher, MR, Peters, JM, Kinzler, KW, Vogelstein, B, Lengauer, C

Cell 2001
12194817 Regulation of human separase by securin binding and autocleavage

Waizenegger, I, Giménez-Abián, JF, Wernic, D, Peters, JM

Curr. Biol. 2002
10411507 Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

Zou, H, McGarry, TJ, Bernal, T, Kirschner, MW

Science 1999
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