Separation of sister chromatids

Stable Identifier
R-HSA-2467811
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The cleavage of RAD21 subunit of centromeric cohesin by ESPL1 (separin i.e. separase) promotes dissociation of cohesin complexes from centromeric chromatin at the onset of anaphase, allowing for sister chromatid separation and segregation of replicated chromosomes to daughter cells (Waizenegger et al. 2000, Hauf et al. 2001, Waizenegger et al. 2002).

Literature References
PubMed ID Title Journal Year
11081627 Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

Waizenegger, IC, Hauf, S, Meinke, A, Peters, JM

Cell 2000
11509732 Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

Hauf, S, Waizenegger, IC, Peters, JM

Science 2001
12194817 Regulation of human separase by securin binding and autocleavage

Waizenegger, I, Giménez-Abián, JF, Wernic, D, Peters, JM

Curr. Biol. 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created