CDK1 phosphorylates CDCA5 (Sororin) at centromeres

Stable Identifier
R-HSA-2468287
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of CDCA5 (Sororin) coincides with dissociation of CDCA5 from chromosomal arms in prometaphase, but phosphorylated CDCA5 persists on centromeres throughout prophase and metaphase. Several serine and threonine residues in CDCA5 are phosphorylated by CDK1 in prometaphase, but only the three sites that perfectly match the CDK1 consensus phosphorylation sequence are shown here - serines S21 and S75 and threonine T159 (Drier et al. 2011, Zhang et al. 2011).

Literature References
PubMed ID Title Journal Year
21987589 Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion

Zhang, N, Panigrahi, AK, Mao, Q, Pati, D

J. Biol. Chem. 2011
21878504 Regulation of sororin by Cdk1-mediated phosphorylation

Dreier, MR, Bekier, ME, Taylor, WR

J. Cell. Sci. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created