CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms

Stable Identifier
R-HSA-2468293
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylation of CDCA5 (Sororin) coincides with dissociation of CDCA5 from chromosomal arms in prometaphase. Several serine and threonine residues in CDCA5 are phosphorylated by CDK1 in prometaphase, but only the three sites that perfectly match the CDK1 consensus phosphorylation sequence are shown here - serines S21 and S75 and threonine T159 (Drier et al. 2011, Zhang et al. 2011).
Literature References
PubMed ID Title Journal Year
21878504 Regulation of sororin by Cdk1-mediated phosphorylation

Dreier, MR, Bekier, ME, Taylor, WR

J. Cell. Sci. 2011
21987589 Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion

Pati, D, Mao, Q, Panigrahi, AK, Zhang, N

J. Biol. Chem. 2011
Participants
Participates
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!