Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C

Stable Identifier
R-HSA-2470483
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
4/5
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Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C
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As inferred from mouse, Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1C (ALK7). It is unclear if the type II receptor and the type I receptor are associated before binding Activin. Activin AB (INHBA:INHBB) and Activin B (INHBB:INHBB), but not Activin A (INHBA:INHBA) can bind and signal via an activin receptor containing the ACVR1C (ALK7) type I receptor. Also, TGFBR3 (Betaglycan) antagonises Activin signalling by binding with Inhibin A and ACVR2A (ActRII). TGFBR3 and Activin compete for ACVR2A and TGFBR3 thus inhibits activin signalling (Lewis et al. 2000, Waiter et al. 2003).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
Inferred From
Activin AB/B binds Activin Receptor Acvr2a:Acvr1c (Mus musculus)
Authored
May, B  (2012-09-13)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2012-09-19)
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