Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
CTSK [extracellular region]
Stable Identifier
R-HSA-2470897
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cathepsin K, CATK_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP7 by MMP3 (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
CTSK [extracellular region] (Homo sapiens)
Initial activation of proMMP13 by MMP3 (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
CTSK [extracellular region] (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type XVIII endostatin release (Homo sapiens)
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
CTSK [extracellular region] (Homo sapiens)
Endostatin degradation by cathepsins (Homo sapiens)
Endostatin-degrading cathepsins [extracellular region] (Homo sapiens)
CTSK [extracellular region] (Homo sapiens)
Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
CTSK [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43235 CTSK
Gene Names
CTSK, CTSO, CTSO2
Chain
signal peptide:1-15, propeptide:16-114, chain:115-329
Reference Genes
BioGPS Gene:1513 CTSK
COSMIC (genes):CTSK CTSK
CTD Gene:1513 CTSK
dbSNP Gene:1513 CTSK
ENSEMBL:ENSG00000143387 CTSK
ENSEMBL_homo_sapiens_GENE:ENSG00000143387.14 CTSK
HGNC:2536 CTSK
KEGG Gene (Homo sapiens):1513 CTSK
Monarch:1513 CTSK
NCBI Gene:1513 CTSK
OMIM:601105 CTSK
UCSC:P43235 CTSK
Reference Transcript
RefSeq:NM_000396.3 CTSK
Other Identifiers
11715496_a_at
128_at
129_g_at
1513
16692846
202450_PM_s_at
202450_s_at
2434610
2434611
2434612
2434614
2434615
2434617
2434618
2434620
2434622
2434625
2434627
2434631
2434632
38466_at
7919815
A_23_P34744
GE80208
GO:0000422
GO:0001957
GO:0001968
GO:0002376
GO:0003824
GO:0004197
GO:0004252
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005764
GO:0005768
GO:0005773
GO:0005886
GO:0006508
GO:0006575
GO:0006590
GO:0006914
GO:0006915
GO:0006955
GO:0007005
GO:0008233
GO:0008234
GO:0008656
GO:0009897
GO:0012501
GO:0014070
GO:0016020
GO:0016324
GO:0016787
GO:0022617
GO:0023052
GO:0030154
GO:0030163
GO:0030198
GO:0030574
GO:0031410
GO:0032868
GO:0034224
GO:0036021
GO:0043202
GO:0043226
GO:0043231
GO:0043394
GO:0045453
GO:0045471
GO:0048856
GO:0051603
GO:0061037
GO:0071356
GO:0071560
GO:0098772
GO:0140096
GO:1903131
GO:2001235
HMNXSV003041133
ILMN_1758895
PH_hs_0004783
TC01003211.hg
X82153_at
g4503150_3p_a_at
Participates
as a member of
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
Endostatin-degrading cathepsins [extracellular region] (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
Other forms of this molecule
CTSK [lysosomal lumen]
CTSK [endolysosome lumen]
Inferred To
CTSK [extracellular region]
(Bos taurus)
CTSK [extracellular region]
(Gallus gallus)
CTSK [extracellular region]
(Sus scrofa)
zgc:110367 [extracellular region]
(Danio rerio)
ctsk [extracellular region]
(Xenopus tropicalis)
Ctsk [extracellular region]
(Mus musculus)
Ctsk [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000387.1
ZINC - World Drugs
CATK_HUMAN
Guide to Pharmacology - Targets
2350
OpenTargets
ENSG00000143387
ZINC - FDA approved
CATK_HUMAN
ZINC - Substances
CATK_HUMAN
ZINC - Biogenic
CATK_HUMAN
ZINC target
P43235
PRO
P43235
PDB
4N8W
,
4N79
,
7PCK
,
5JH3
,
7NXL
,
7NXM
,
5Z5O
,
4YVA
,
6QBS
,
2ATO
,
1AYW
,
5J94
,
1AYV
,
1AYU
,
6QM0
,
6QLX
,
4YV8
,
3KW9
,
1AU3
,
1AU2
,
1AU0
,
4X6J
,
1U9X
,
1U9W
,
2BDL
,
6ASH
,
1AU4
,
2AUZ
,
6HGY
,
3H7D
,
1BY8
,
2AUX
,
4X6H
,
6PXF
,
5TUN
,
4X6I
,
1NL6
,
3C9E
,
1MEM
,
1YK8
,
7QBM
,
1NLJ
,
8C3D
,
2R6N
,
1ATK
,
1YK7
,
3OVZ
,
6QLW
,
7QBN
,
4DMX
,
3KWZ
,
4DMY
,
7QBO
,
3KX1
,
1BGO
,
1SNK
,
3O1G
,
6QLM
,
7QBL
,
5TDI
,
1VSN
,
5JA7
,
3O0U
,
6QL8
,
1Q6K
,
3KWB
,
1YT7
,
1U9V
,
1TU6
ZINC - Investigational
CATK_HUMAN
ZINC - Metabolites
CATK_HUMAN
IntEnz
3.4.22.38
GeneCards
P43235
HPA
ENSG00000143387-CTSK
Ensembl
ENSP00000503723
,
ENSP00000504176
,
ENST00000676824
,
ENST00000676966
,
ENST00000271651
,
ENSP00000271651
,
ENSG00000143387
Pharos - Targets
P43235
ZINC - Predictions - Purchasable
CATK_HUMAN
Orphanet
15823
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text