Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2

Stable Identifier
R-HSA-2470935
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cohesin, in complex with WAPAL and PDS5 (PDS5A or PDS5B) binds decondensed chromatin in telophase (Kueng et al. 2006). This binding is facilitated by the NIPBL:MAU2 complex, also known as the 'cohesin loading complex'. NIPBL:MAU2 complex is associated with chromatin from telophase until prophase (Watrin et al. 2006) but seems to form a transient rather than stable complex with cohesin.

Literature References
PubMed ID Title Journal Year
16682347 Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression

Watrin, E, Schleiffer, A, Tanaka, K, Eisenhaber, F, Nasmyth, K, Peters, JM

Curr. Biol. 2006
17113138 Wapl controls the dynamic association of cohesin with chromatin

Kueng, S, Hegemann, B, Peters, BH, Lipp, JJ, Schleiffer, A, Mechtler, K, Peters, JM

Cell 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!