Endostatin degradation by cathepsins

Stable Identifier
R-HSA-2471621
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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As well as generating endostatin from collagen XVIII, cathepsins L and B quickly degrade it, as do cathepsins D and K. In contrast MMPs that produce endostatin do not cleave it further (Ferreras et al. 2000).

Literature References
PubMed ID Title Journal Year
11119712 Generation and degradation of human endostatin proteins by various proteinases

Ferreras, M, Felbor, U, Lenhard, T, Olsen, BR, Delaissé, J

FEBS Lett. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Endostatin-degrading cathepsins [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created