Collagen type XXV ectomain shedding

Stable Identifier
R-HSA-2471842
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Identified as a component of amyloid plaques in Alzheimer's brain, the ectodomain of type XXV collagen (known as CLAC) is released by furin convertase activity (Hashimoto et al. 2002). The presence of CLAC leads to Abeta fibril bundles that have an increased resistance to proteases (Söderberg et al. 2005).

Literature References
PubMed ID Title Journal Year
11927537 CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

Hashimoto, T, Wakabayashi, T, Watanabe, A, Kowa, H, Hosoda, R, Nakamura, A, Kanazawa, I, Arai, T, Takio, K, Mann, DM, Iwatsubo, T

EMBO J. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of FURIN [plasma membrane]
Physical Entity
Activity
Authored
Reviewed
Created