CDCA5 (Sororin) enables cohesion of sister centromeres

Stable Identifier
R-HSA-2473151
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm, chromosome, centromeric region
ReviewStatus
5/5
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CDCA5 (Sororin) enables cohesion of sister centromeres
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CDCA5 (Sororin) is essential for the establishment of sister chromatid cohesion at centromeres. Experiments in which a recombinant tagged mouse CDCA5 was expressed in human HeLa cell line showed that CDCA5 starts to accumulate on chromatin in S-phase and dissociates from centromeres in anaphase (Nishiyama et al. 2010).
Literature References
PubMed ID Title Journal Year
21111234 Sororin mediates sister chromatid cohesion by antagonizing Wapl

Kreidl, E, Ladurner, R, Hyman, AA, Peters, JM, Bando, M, Mechtler, K, Bhaskara, V, Schleiffer, A, Schmitz, J, Nishiyama, T, Shirahige, K

Cell 2010
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Orthologous Events
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Authored
Orlic-Milacic, M  (2012-10-02)
Reviewed
Zhang, N  (2012-10-22)
Watanabe, Y  (2012-11-20)
Tanno, Y  (2012-11-20)
Created
Orlic-Milacic, M  (2012-09-21)
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