Diseases associated with visual transduction

Stable Identifier
Homo sapiens
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The process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defects in the genes involved in the retinoid cycle cause degenerative retinal diseases. These defective genes are described here (for reviews see Travis et al. 2007, Palczewski 2010, Fletcher et al. 2011, den Hollander et al. 2008).

Literature References
PubMed ID Title Journal Year
18632300 Leber congenital amaurosis: genes, proteins and disease mechanisms

den Hollander, AI, Roepman, R, Koenekoop, RK, Cremers, FP

Prog Retin Eye Res 2008
20435355 Retinoids for treatment of retinal diseases

Palczewski, K

Trends Pharmacol. Sci. 2010
16968212 Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

Travis, GH, Golczak, M, Moise, AR, Palczewski, K

Annu. Rev. Pharmacol. Toxicol. 2007
21377628 Animal models of retinal disease

Fletcher, EL, Jobling, AI, Vessey, KA, Luu, C, Guymer, RH, Baird, PN

Prog Mol Biol Transl Sci 2011
Participant Of
Name Identifier Synonyms
retinal disease 5679 Retinopathy (disorder), Retinal disorder, retina disorder