Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13

Stable Identifier
R-HSA-2485148
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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All mammals have three fibrillin genes (Davis & Summers 2012). Fibrillin-3 arose as a duplication of fibrillin-2 that did not occur in the rodent lineage. Fibrillin-1 is the major structural component of microfibrils (Kielty et al. 2005). Fibrillin-2 is expressed earlier in development than fibrillin-1 and may be important for elastic fiber formation (Zhang et al. 1994). Fibrillin-3 was isolated from and is predominantly expressed in brain; it is not known whether it forms microfibrils (Corson et al. 2004). Fibrillin-1 and -2 are degraded by MMP2, 9, 12 and 13 (Ashworth et al. 1999, Hindson et al. 1999). Fibrillin-1 is additionally degraded by MMP3 (Ashworth et al. 1999), the membrane-associated MMP14 (Ashworth et al. 1999), neutrophil elastase (ELANE) (Kielty et al. 1994), cathepsin L2 (V) and cathepsin K (Kirschner et al. 2011).

Literature References
PubMed ID Title Journal Year
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Ashworth, JL, Murphy, G, Rock, MJ, Sherratt, MJ, Shapiro, SD, Shuttleworth, CA, Kielty, CM

Biochem. J. 1999
10386589 Fibrillin degradation by matrix metalloproteinases: identification of amino- and carboxy-terminal cleavage sites

Hindson, VJ, Ashworth, JL, Rock, MJ, Cunliffe, S, Shuttleworth, CA, Kielty, CM

FEBS Lett. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP2,9,12,13 [extracellular region]
Physical Entity
Activity
Orthologous Events
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