NUDT16 hydrolyses dIDP to dIMP

Stable Identifier
R-HSA-2509793
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
dIDP + H2O => dIMP + Pi
ReviewStatus
5/5
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NUDT16 dimer catalyzes the reaction of dIDP and water to form dIMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).
Literature References
PubMed ID Title Journal Year
20385596 NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

Iyama, T, Nakabeppu, Y, Abolhassani, N, Nonaka, M, Tsuchimoto, D

Nucleic Acids Res. 2010
17567574 Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

Peculis, BA, Cleland, M, Reynolds, K

J. Biol. Chem. 2007
Participants
Participates
Catalyst Activity

dIDP diphosphatase activity of NUDT16 dimer [nucleoplasm]

This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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