Fibrillin-1 degradation by MMP3, CTSK, CTSL2

Stable Identifier
R-HSA-2514772
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Fibrillin-1 can be degraded by MMP3 (Ashworth et al. 1999) and cathepsins K and L2 (V) (Kirschner et al. 2011).

Literature References
PubMed ID Title Journal Year
21784848 Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function

Kirschner, R, Hubmacher, D, Iyengar, G, Kaur, J, Fagotto-Kaufmann, C, Brömme, D, Bartels, R, Reinhardt, DP

J. Biol. Chem. 2011
10229672 Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

Ashworth, JL, Murphy, G, Rock, MJ, Sherratt, MJ, Shapiro, SD, Shuttleworth, CA, Kielty, CM

Biochem. J. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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