Inactivation, recovery and regulation of the phototransduction cascade

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R-HSA-2514859
Type
Pathway
Species
Homo sapiens
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Summation

To terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GNAT1-GTP) and phosphodiesterase 6 (PDE6) all need to be efficiently deactivated. In addition, the cGMP concentrations must be restored to support reopening of the CNG channels. This section describes the inactivation and recovery events of the activated intermediates involved in phototransduction (Burns & Pugh 2010, Korenbrot 2012).

Literature References
PubMed ID Title Journal Year
20430952 Lessons from photoreceptors: turning off G-protein signaling in living cells

Burns, ME, Pugh, EN

Physiology (Bethesda) 2010
22658984 Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models

Korenbrot, JI

Prog Retin Eye Res 2012
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