CK2 phosphorylates condensin I subunits

Stable Identifier
R-HSA-2529020
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Protein levels of condensin subunits are constant during the cell cycle. Four subunits, SMC4, NCAPD2, NCAPG and NCAPH, are phosphorylated in interphase cells (Takemoto et al. 2004) by CK2 i.e. casein kinase II (Takemoto et al. 2006). Except for the phosphorylation of NCAPH subunit on serine residue S570, CK2 phosphorylation sites in condensin I subunits have not been identified. Phosphorylation by CK2 inhibits condensin I-mediated introduction of positive supercoils into DNA and chromatin condensation. Mitotic activation of condensin I involves removal of phosphate groups added by CK2 (Takemoto et al. 2006), but the responsible phosphatase has not been identified.

Literature References
PubMed ID Title Journal Year
14607834 Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin

Takemoto, A, Kimura, K, Yokoyama, S, Hanaoka, F

J. Biol. Chem. 2004
17066080 Negative regulation of condensin I by CK2-mediated phosphorylation

Takemoto, A, Kimura, K, Yanagisawa, J, Yokoyama, S, Hanaoka, F

EMBO J. 2006
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Catalyst Activity
Catalyst Activity
Title
kinase activity of Casein kinase II [cytosol]
Physical Entity
Activity
Orthologous Events
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