Reactome | CD59 [plasma membrane]

CD59 [plasma membrane]

Stable Identifier

R-HSA-2530458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P13987 CD59

Gene Names

CD59, MIC11, MIN1, MIN2, MIN3, MSK21

Chain

signal peptide:1-25, chain:26-102, propeptide:103-128

Reference Genes

BioGPS Gene:966 CD59

COSMIC (genes):CD59 CD59

CTD Gene:966 CD59

dbSNP Gene:966 CD59

ENSEMBL:ENSG00000085063 CD59

ENSEMBL_homo_sapiens_GENE:ENSG00000085063.18 CD59

HGNC:1689 CD59

KEGG Gene (Homo sapiens):966 CD59

Monarch:966 CD59

NCBI Gene:966 CD59

OMIM:107271 CD59

Reference Transcript

Other Identifiers

11718100_s_at

11718101_at

11718102_at

11757306_s_at

16737194

16737200

200983_PM_x_at

200983_x_at

200984_PM_s_at

200984_s_at

200985_PM_s_at

200985_s_at

212463_PM_at

212463_at

228748_PM_at

228748_at

3368706

3368708

3368709

3368710

3368711

3368712

3368713

3368714

3368715

3368716

3368717

3368718

3368719

3368720

3368721

3368722

3368723

3368724

3368725

3368726

3368727

3368728

3368729

3368730

3368734

3368737

3368738

3368739

3368740

3368741

3368742

3368743

3368745

3368746

3368747

39170_at

39351_at

62133_at

7947425

966

A_23_P75523

A_24_P141481

A_24_P639441

A_24_P784765

A_33_P3409746

GE56215

GE79480

GE88415

GO:0000139

GO:0001848

GO:0001971

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005925

GO:0007166

GO:0007596

GO:0009897

GO:0009986

GO:0012507

GO:0016020

GO:0023052

GO:0030133

GO:0030449

GO:0031410

GO:0031982

GO:0033116

GO:0035579

GO:0042060

GO:0043226

GO:0070062

GO:0070821

GO:0098552

GO:1903659

HMNXSV003026907

HMNXSV003054760

Hs.119663.0.S1_3p_a_at

Hs.119663.0.S2_3p_a_at

Hs.293774.0.A1_3p_at

Hs.99766.0.S1_3p_at

ILMN_1669659

ILMN_1724789

ILMN_2333687

M84349_at

PH_hs_0014290

TC11001540.hg

TC11003112.hg

TC11003113.hg

g10835164_3p_a_at

Participates

as a member of

as a component of

CD59:C5b-C9 [plasma membrane] (Homo sapiens)

as an input of

CD59 inhibits MAC formation (Homo sapiens)

Other forms of this molecule

GPI-CD59 [Golgi membrane]

GPI-CD59 [transport vesicle]

GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]

GPI-CD59 [ER to Golgi transport vesicle membrane]

GPI-CD59 [endoplasmic reticulum membrane]

CD59 [specific granule membrane]

CD59 [tertiary granule membrane]

Inferred To

Cd59b [plasma membrane] (Mus musculus)

Cd59 [plasma membrane] (Rattus norvegicus)

ly97.3 [plasma membrane] (Danio rerio)

CD59 [plasma membrane] (Bos taurus)

CD59 [plasma membrane] (Canis familiaris)

CD59 [plasma membrane] (Gallus gallus)

CD59 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_976074.1, NP_976076.1, NP_001120698.1, NP_001120695.1, NP_976075.1, NP_001120699.1, NP_000602.1, NP_001120697.1

OpenTargets

ENSG00000085063

GeneCards

P13987

HPA

ENSG00000085063-CD59

Ensembl

ENSP00000432942, ENSP00000404822, ENST00000527577, ENSP00000379191, ENSP00000498448, ENSP00000494884, ENSP00000340210, ENST00000437761, ENST00000415002, ENST00000642928, ENSP00000410182, ENSG00000085063, ENST00000351554, ENSP00000498879, ENST00000445143, ENST00000651785, ENSP00000403511, ENST00000395850, ENST00000652678

PRO

P13987

Pharos - Targets

P13987

Orphanet

18955

PDB

8B0G, 5IMT, 2J8B, 8B0H, 6ZD0, 1CDR, 1ERG, 8B0F, 1CDQ, 2UX2, 2OFS, 1ERH, 5IMY, 4BIK, 2UWR, 1CDS

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	9
UniProt:Q15363 TMED2	5	TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [transport vesicle] (R-HSA-6808806) TMED2 [Golgi membrane] (R-HSA-6808804)	0.576	4
UniProt:O35587 TMEDA			0.576	5
UniProt:Q5JX71 F209A			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q778I9 Q778I9			0.537	4
UniProt:Q01415 GALK2			0.527	2
UniProt:Q86T26 TM11B			0.527	2

Cite Us!