Reactome | FNTB [cytosol]

FNTB [cytosol]

Stable Identifier

R-HSA-2530482

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein farnesyltransferase subunit beta, FNTB_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
        
        FNTA:FNTB [cytosol] (Homo sapiens)
        
        FNTB [cytosol] (Homo sapiens)
        
        FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
        
        FNTA:FNTB [cytosol] (Homo sapiens)
        
        FNTB [cytosol] (Homo sapiens)

Sensory Perception (Homo sapiens)

- Visual phototransduction (Homo sapiens)
  - The phototransduction cascade (Homo sapiens)
    - Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
      - FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
        
        FNTA:FNTB [cytosol] (Homo sapiens)
        
        FNTB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49356 FNTB

Gene Names

FNTB

Chain

chain:1-437

Reference Genes

BioGPS Gene:100529261 FNTB

BioGPS Gene:2342 FNTB

COSMIC (genes):FNTB FNTB

CTD Gene:100529261 FNTB

CTD Gene:2342 FNTB

dbSNP Gene:100529261 FNTB

dbSNP Gene:2342 FNTB

ENSEMBL:ENSG00000257365 FNTB

ENSEMBL_homo_sapiens_GENE:ENSG00000257365.8 FNTB

HGNC:3785 FNTB

KEGG Gene (Homo sapiens):100529261 FNTB

KEGG Gene (Homo sapiens):2342 FNTB

Monarch:100529261 FNTB

Monarch:2342 FNTB

NCBI Gene:100529261 FNTB

NCBI Gene:2342 FNTB

OMIM:134636 FNTB

UCSC:P49356 FNTB

Reference Transcript

Other Identifiers

100529261

11718033_a_at

11749762_a_at

11757811_s_at

1773_PM_at

1773_at

204764_PM_at

204764_at

225851_PM_at

225851_at

2342

3540403

3540404

3540405

3540414

3540421

3540423

3540432

3540433

3540436

3540438

3540439

3540440

3540444

3540447

3540451

3540452

37488_at

51164_at

7975121

A_14_P109310

A_23_P25835

A_24_P124831

GE57543

GO:0003824

GO:0004659

GO:0004660

GO:0005515

GO:0005829

GO:0005856

GO:0005875

GO:0005965

GO:0006629

GO:0008270

GO:0008318

GO:0016740

GO:0018343

GO:0036211

GO:0043226

GO:0046872

GO:0140096

HMNXSV003049239

Hs.276.0.A1_3p_at

ILMN_1728517

L00635_at

PH_hs_0000037

TC14002300.hg

g10835058_3p_s_at

Participates

as a component of

FNTA:FNTB [cytosol] (Homo sapiens)

Inferred To

FNTB [cytosol] (Bos taurus)

FNTB [cytosol] (Dictyostelium discoideum)

FNTB [cytosol] (Gallus gallus)

FNTB [cytosol] (Mus musculus)

FNTB [cytosol] (Plasmodium falciparum)

FNTB [cytosol] (Rattus norvegicus)

FNTB [cytosol] (Saccharomyces cerevisiae)

FNTB [cytosol] (Schizosaccharomyces pombe)

Fntb [cytosol] (Drosophila melanogaster)

wu:fb99h09 [cytosol] (Danio rerio)

fntb-1 [cytosol] (Caenorhabditis elegans)

fntb [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002019.1, NP_001189487.1

Guide to Pharmacology - Targets

2826

OpenTargets

ENSG00000257365

GeneCards

P49356

HPA

ENSG00000257365-FNTB

ZINC target

P49356

Ensembl

ENSP00000246166, ENSG00000257365, ENST00000246166

PRO

P49356

Pharos - Targets

P49356

HMDB Protein

HMDBP10637

PDB

2F0Y, 2H6H, 2H6G, 1LD7, 3E37, 1TN6, 2IEJ, 2H6F, 1SA4, 1MZC, 1S63, 1LD8, 2H6I, 1JCQ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49354 FNTA	3	FNTA(59-379) [cytosol] (R-HSA-202872) FNTA(1-59) [cytosol] (R-HSA-202869) FNTA(2-379) [cytosol] (R-HSA-2530516)	0.951	13
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3