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ADAMTS4 [extracellular region]
Stable Identifier
R-HSA-2533998
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
A disintegrin and metalloproteinase with thrombospondin motifs 4, ATS4_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Aggrecan degradation by ADAMTSs (Homo sapiens)
ADAMTS4, 5, (1, 8, 9, 16, 18) [extracellular region] (Homo sapiens)
ADAMTS4 [extracellular region] (Homo sapiens)
Brevican degradation by ADAMTS4, ADAMTS5 (Homo sapiens)
ADAMTS4, ADAMTS5 [extracellular region] (Homo sapiens)
ADAMTS4 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75173 ADAMTS4
Gene Names
ADAMTS4, KIAA0688, UNQ769/PRO1563
Chain
signal peptide:1-51, propeptide:52-212, chain:213-837
Reference Genes
BioGPS Gene:9507 ADAMTS4
COSMIC (genes):ADAMTS4 ADAMTS4
CTD Gene:9507 ADAMTS4
dbSNP Gene:9507 ADAMTS4
ENSEMBL:ENSG00000158859 ADAMTS4
HGNC:220 ADAMTS4
KEGG:hsa:9507 ADAMTS4
Monarch:9507 ADAMTS4
NCBI Gene:9507 ADAMTS4
OMIM:603876 ADAMTS4
UCSC:O75173 ADAMTS4
Reference Transcript
RefSeq:NM_005099.5 ADAMTS4
RefSeq:NM_001320336.3 ADAMTS4
Other Identifiers
11730923_x_at
11752079_x_at
1555380_PM_at
1555380_at
16695627
238312_PM_s_at
238312_s_at
2440696
2440697
2440698
2440699
2440701
2440702
2440703
2440704
2440705
2440706
2440707
2440708
2440709
2440710
2440711
2440712
2440713
2440714
2440715
2440716
2440717
2440718
2440722
2440723
2440724
7921821
83744_at
9507
A_23_P360754
A_24_P128163
GE532164
GE578983
GE61341
GO:0001501
GO:0002020
GO:0003824
GO:0004222
GO:0005515
GO:0005576
GO:0005615
GO:0006508
GO:0008233
GO:0008237
GO:0008270
GO:0016020
GO:0016607
GO:0016787
GO:0022617
GO:0030198
GO:0030312
GO:0031012
GO:0046872
GO:0048856
GO:0062023
GO:0140096
HMNXSV003000983
HMNXSV003012327
HMNXSV003048563
Hs.157267.1.A1_3p_at
Hs2.211604.2.S1_3p_at
Hs2.211604.2.S1_3p_x_at
ILMN_2092933
PH_hs_0009855
PH_hs_0012277
TC01003421.hg
Participates
as a member of
ADAMTS4, 5, (1, 8, 9, 16, 18) [extracellular region] (Homo sapiens)
ADAMTS4, ADAMTS5 [extracellular region] (Homo sapiens)
Other forms of this molecule
ADAMTS4 [endoplasmic reticulum lumen]
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
O-fuc-ADAMTS4 [endoplasmic reticulum lumen]
Inferred To
ADAMTS4 [extracellular region]
(Bos taurus)
ADAMTS4 [extracellular region]
(Canis familiaris)
ADAMTS4 [extracellular region]
(Gallus gallus)
ADAMTS4 [extracellular region]
(Sus scrofa)
Adamts4 [extracellular region]
(Mus musculus)
Adamts4 [extracellular region]
(Rattus norvegicus)
adamts4 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001307265.1
,
NP_005090.3
Guide to Pharmacology - Targets
1677
ENSEMBL
ENST00000367996
,
ENSP00000356975
,
ENSG00000158859
OpenTargets
ENSG00000158859
GeneCards
ADAMTS4
HPA
ENSG00000158859-ADAMTS4
ZINC - Substances
ATS4_HUMAN
ZINC target
O75173
PRO
O75173
Pharos - Targets
O75173
ZINC - Predictions - Purchasable
ATS4_HUMAN
PDB
4WK7
,
4WKI
,
4WKE
,
3B2Z
,
2RJP
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.527
2
UniProt:Q13490 BIRC2
5
BIRC2 [cytosol]
(R-HSA-50847)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
0.527
3
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.527
3
UniProt:O00462 MANBA
3
MANBA [plasma membrane]
(R-HSA-6806257)
MANBA [azurophil granule membrane]
(R-HSA-6799128)
MANBA [lysosomal lumen]
(R-HSA-8853711)
0.527
2
UniProt:Q7L8W6 DPH6
1
DPH6 [cytosol]
(R-HSA-5358469)
0.527
2
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