METAP1/2 demethylates GNAT1

Stable Identifier
R-HSA-2534096
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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All eukaryotic proteins synthesized in the cytosol are initiated by methionine (Met). For the maturation of many proteins, the removal of N-terminal Met is essential and is mediated by methionine-aminopeptidases (METAPs). In human, there are two forms, METAP1 and 2 (Arfin et al. 1995). These enzymes utilise 2 cobalt ions (Co2+) as cofactors (Addlagatta et al. 2005, Hu et al. 2006, Marino et al. 2007).

Literature References
PubMed ID Title Journal Year
7644482 Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes

Arfin, SM, Kendall, RL, Hall, L, Weaver, LH, Stewart, AE, Matthews, BW, Bradshaw, RA

Proc. Natl. Acad. Sci. U.S.A. 1995
16274222 Structural basis for the functional differences between type I and type II human methionine aminopeptidases

Addlagatta, A, Hu, X, Liu, JO, Matthews, BW

Biochemistry 2005
17636946 Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore

Marino, JP, Fisher, PW, Hofmann, GA, Kirkpatrick, RB, Janson, CA, Johnson, RK, Ma, C, Mattern, M, Meek, TD, Ryan, MD, Schulz, C, Smith, WW, Tew, DG, Tomazek, TA, Veber, DF, Xiong, WC, Yamamoto, Y, Yamashita, K, Yang, G, Thompson, SK

J. Med. Chem. 2007
17114291 Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression

Hu, X, Addlagatta, A, Lu, J, Matthews, BW, Liu, JO

Proc. Natl. Acad. Sci. U.S.A. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aminopeptidase activity of METAP1/2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created