HSPG2 (perlecan) degradation by MMP13, CTSS

Stable Identifier
R-HSA-2534160
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Degradation of perlecan by MMP13, CTSS
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The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. For example, HS-bound FGF was released from cultured cells by treatments with MMP3, rat MMP13, and plasmin (Whitelock et al. 1996). The core protein of HSPG2 can be cleaved by cathepsin S (Liuzzo et al. 1999).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP13, CTSS [extracellular region]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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