HSPG2 (perlecan) degradation by MMP14, MMP15

Stable Identifier
R-HSA-2534240
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Degradation of perlecan by MMP14, MMP15
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HSPG2 protein (perlecan) consists of a core protein of molecular weight 470 kDa with three long glycosaminoglycan (GAG) chains attached, each approximately 70-100 kDa. The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. MMP14 and MMP15 (MT1-MMP and MT2-MMP) can degrade HSPG2 (d'Ortho et al. 1997).

Literature References
PubMed ID Title Journal Year
9461298 Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases

d'Ortho, MP, Will, H, Atkinson, S, Butler, G, Messent, A, Gavrilovic, J, Smith, B, Timpl, R, Zardi, L, Murphy, G

Eur J Biochem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP14, MMP15 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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