Reactome | PSEN1(299-467) [plasma membrane]

PSEN1(299-467) [plasma membrane]

Stable Identifier

R-HSA-2534245

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Presenilin-1 C-terminal fragment, Presenilin-1 CTF subunit

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        gamma-secretase cleaves EPHB2 (Homo sapiens)
        
        gamma-secretase complex [plasma membrane] (Homo sapiens)
        
        Presenilin [plasma membrane] (Homo sapiens)
        
        PSEN1 [plasma membrane] (Homo sapiens)
        
        PSEN1(299-467) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49768 PSEN1

Gene Names

PSEN1, AD3, PS1, PSNL1

Chain

chain:1-298, chain:299-467, chain:346-467

Reference Genes

COSMIC (genes):PSEN1 PSEN1

dbSNP Gene:5663 PSEN1

ENSEMBL:ENSG00000080815 PSEN1

Participates

as a member of

Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)

as a component of

PSEN1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

PSEN1(1-467) [plasma membrane]

PSEN1(299-467) [azurophil granule membrane]

PSEN1(1-467) [azurophil granule membrane]

PSEN1(1-298) [azurophil granule membrane]

PSEN1(1-298) [plasma membrane]

Inferred To

psenA [plasma membrane] (Dictyostelium discoideum)

psen1 [plasma membrane] (Danio rerio)

psen1 [plasma membrane] (Xenopus tropicalis)

psenB [plasma membrane] (Dictyostelium discoideum)

PSEN1 [plasma membrane] (Bos taurus)

PSEN1 [plasma membrane] (Canis familiaris)

PSEN1 [plasma membrane] (Gallus gallus)

PSEN1 [plasma membrane] (Sus scrofa)

Homologues of PSEN1(299-467) [plasma membrane] (Dictyostelium discoideum)

Psen1 [plasma membrane] (Rattus norvegicus)

Psen1(299-467) [plasma membrane] (Mus musculus)

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067-4 APP	2	APP (535-695) [cytosol] (R-HSA-9839084) APP [mitochondrial inner membrane] (R-HSA-9839060)	0.702	4
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.697	4
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.639	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.632	6
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.599	5
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.582	4
UniProt:P12830 CDH1	8	CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(732-882) [plasma membrane] (R-HSA-3827997)	0.564	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.508	2
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.462	3
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	3

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