Interaction With Cumulus Cells And The Zona Pellucida

Stable Identifier
R-HSA-2534343
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

A typical mammalian egg is surrounded by an outer layer of about 3,000 cumulus cells embedded in an extracellular matrix rich in hyaluronic acid. It is suggested that the fertilizing sperm with it's acrosome intact, passes through the cumulus cell layer. The zona pellucida (ZP), a glycoproteinaceous matrix surrounding the mammalian oocyte plays an important role in species specific sperm-egg binding, induction of acrosome reaction in the ZP bound spermatozoa, avoidance of polyspermy and protection of the embryo prior to implantation. The human ZP matrix is composed of 4 glycoproteins designated as ZP1, ZP2, ZP3 and ZP4.

Literature References
PubMed ID Title Journal Year
8195297 A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg

Lin, Y, Mahan, K, Lathrop, WF, Myles, DG, Primakoff, P

J Cell Biol 1994
20364096 Fertilization: a sperm's journey to and interaction with the oocyte

Ikawa, M, Inoue, N, Benham, AM, Okabe, M

J Clin Invest 2010
Participants
Participant Of
hasEvent
Event Information
Go Biological Process
Orthologous Events
Authored
Reviewed
Created