SPAM1 Binds Hyaluronic Acid

Stable Identifier
R-HSA-2534346
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The fertilizing spermatozoon must penetrate the surrounding cumulus mass, (or cumulus oophorus), consisting of follicular cells dispersed in a polymerized matrix composed mainly of hyaluronic acid.

Literature References
PubMed ID Title Journal Year
8195297 A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg

Lin, Y, Mahan, K, Lathrop, WF, Myles, DG, Primakoff, P

J Cell Biol 1994
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Orthologous Events
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