Slo3 Potassium Transport

Stable Identifier
R-HSA-2534365
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Slo3 represents a new and unique type of potassium channel regulated by intracellular pH. Slo3 is sperm specific and controls membrane potential. Incapacitated murine spermatozoa hyperpolarize to approximately 60 mV during capacitation, an effect attributed to an increase in K+ permeability. KSper (potassium transport in sperm) is the dominant, if not the only, K+ selective channel in mouse epididymal spermatozoa.
Literature References
PubMed ID Title Journal Year
9452476 Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes

Schreiber, M, Saito, M, Yuan, A, Salkoff, L, Gaut, J, Wei, A

J. Biol. Chem. 1998
17460039 KSper, a pH-sensitive K+ current that controls sperm membrane potential

Clapham, DE, Navarro, B, Kirichok, Y

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Input
Participates
Catalyst Activity

potassium channel activity of Slo3 Channel [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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