Reactome: A Curated Pathway Database

Fibulin-1 and -2 bind fibronectin

Stable Identifier
R-HSA-2537665
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
FBLN1, FBLN2 bind fibronectin
Locations in the PathwayBrowser
Summation

Fibulins are a family of 7 extracellular calcium binding proteins that have developmental roles (Twal et al. 2001). Fibulins 1-5 are found in association with elastic fibers. Fibulin-1 binds fibronectin (Balbona et al. 1992, Tran et al. 1997) suppressing fibronectin-mediated inhibitory effects on cell attachment and spreading (Twal et al. 2001). Fibulin-2 also binds fibronectin (Sasaki et al. 1995).

Literature References
Participants
Participant Of
Orthologous Events