Fibulin-1 and -2 bind fibronectin

Stable Identifier
R-HSA-2537665
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
FBLN1, FBLN2 bind fibronectin
Locations in the PathwayBrowser
Summation

Fibulins are a family of 7 extracellular calcium binding proteins that have developmental roles (Twal et al. 2001). Fibulins 1-5 are found in association with elastic fibers. Fibulin-1 binds fibronectin (Balbona et al. 1992, Tran et al. 1997) suppressing fibronectin-mediated inhibitory effects on cell attachment and spreading (Twal et al. 2001). Fibulin-2 also binds fibronectin (Sasaki et al. 1995).

Literature References
PubMed ID Title Journal Year
1400330 Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin

Balbona, K, Tran, H, Godyna, S, Ingham, KC, Strickland, DK, Argraves, WS

J. Biol. Chem. 1992
7500359 Binding of mouse and human fibulin-2 to extracellular matrix ligands

Sasaki, T, Göhring, W, Pan, TC, Chu, ML, Timpl, R

J. Mol. Biol. 1995
Participants
Participant Of
Orthologous Events
Authored
Reviewed