Deacetylation of cohesin

Stable Identifier
R-HSA-2545253
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

HDAC8 deacetylates cohesin in prometaphase, after cohesin dissociates from chromosomal arms (Deardorff et al. 2012).

Literature References
PubMed ID Title Journal Year
22885700 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

Deardorff, MA, Bando, M, Nakato, R, Watrin, E, Itoh, T, Minamino, M, Saitoh, K, Komata, M, Katou, Y, Clark, D, Cole, KE, De Baere, E, Decroos, C, Di Donato, N, Ernst, S, Francey, LJ, Gyftodimou, Y, Hirashima, K, Hullings, M, Ishikawa, Y, Jaulin, C, Kaur, M, Kiyono, T, Lombardi, PM, Magnaghi-Jaulin, L, Mortier, GR, Nozaki, N, Petersen, MB, Seimiya, H, Siu, VM, Suzuki, Y, Takagaki, K, Wilde, JJ, Willems, PJ, Prigent, C, Gillessen-Kaesbach, G, Christianson, DW, Kaiser, FJ, Jackson, LG, Hirota, T, Krantz, ID, Shirahige, K

Nature 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone deacetylase activity of HDAC8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed