TLR6/2 ligand associates with CD14 and CD36 within lipid rafts

Stable Identifier
R-HSA-2559464
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Chlamydia trachomatis
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
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Scavenger receptor CD36 has been reported to function as an essential co-receptor involved in recognition of LTA and certain diacylated lipoproteins and presenting them to the TLR2:TLR6 heterodimer at the cell surface. CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been also implicated in TLR2:TLR6 signaling [Stuart L et al 2005; Hoebe KP et al 2005; Triantafilou M et al 2006; Nilsen NJ et al 2008]
Literature References
PubMed ID Title Journal Year
18178856 The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14

Bas, S, Neff, L, Vuillet, M, Spenato, U, Seya, T, Matsumoto, M, Gabay, C

J. Immunol. 2008
16880211 Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

Triantafilou, M, Gamper, FG, Haston, RM, Mouratis, MA, Morath, S, Hartung, T, Triantafilou, K

J. Biol. Chem. 2006
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Authored
Shamovsky, V  (2012-05-15)
Reviewed
D'Eustachio, P  (2006-07-04)
Gillespie, ME  (2010-11-30)
Granucci, F  (2012-11-13)
Zanoni, I  (2012-11-13)
Created
Shamovsky, V  (2012-11-02)
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