LPS treatment led to a rapid increase of the SARM expression in peripheral blood mononuclear cells (PBMCs) and as a result an increased association between SARM and TICAM1 (Carty M et al. 2006). Moreover, suppression of endogenous SARM expression by siRNA led to enhanced TLR4-dependent gene induction in both transformed HEK293 and primary PBMC cells, while endotoxin-tolerant human monocytes showed increased expression of SARM and decreased activation of TICAM1-dependent cytokines (Carty M et al. 2006; Piao W et al. 2009). Thus, SARM negatively regulates TICAM1 (TRIF)-dependent TLR4 signaling pathway.
Chen, H, Piao, W, Fitzgerald, KA, Li, L, Diaz, MA, Medvedev, AE, Wahl, LM, Song, C
Schröder, M, Stack, J, Moynagh, PN, Carty, M, Bowie, AG, Goodbody, R
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