Reactome: A Curated Pathway Database

Collagen type IV sulfilimine cross-linking by peroxidasin

Stable Identifier
R-HSA-2559639
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A recently discovered sulfilimine (S=N) bond between a methionine sulfur and hydroxylysine nitrogen reinforces the collagen IV network (Vanacore et al. 2005, 2009). Peroxidasin, an enzyme found in basement membranes, indirectly catalyzes formation of the sulfilimine bond by producing the reactive intermediates hypobromous acid from peroxide and free Br- (Bhave 2012, MacCall et al. 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
peroxidase activity of PXDN:Br- [extracellular region] PXDN:Br- [extracellular region] peroxidase activity (0004601)
Orthologous Events