Collagen type IV sulfilimine cross-linking by peroxidasin

Stable Identifier
R-HSA-2559639
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A recently discovered sulfilimine (S=N) bond between a methionine sulfur and hydroxylysine nitrogen reinforces the collagen IV network (Vanacore et al. 2005, 2009). Peroxidasin, an enzyme found in basement membranes, indirectly catalyzes formation of the sulfilimine bond by producing the reactive intermediates hypobromous acid from peroxide and free Br- (Bhave 2012, MacCall et al. 2014).

Literature References
PubMed ID Title Journal Year
19729652 A sulfilimine bond identified in collagen IV

Vanacore, RM, Ham, AJ, Voehler, M, Sanders, CR, Conrads, TP, Veenstra, TD, Sharpless, KB, Dawson, PE, Hudson, BG

Science 2009
22842973 Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis

Bhave, G, Cummings, CF, Vanacore, RM, Kumagai-Cresse, C, Ero-Tolliver, IA, Rafi, M, Kang, JS, Pedchenko, V, Fessler, LI, Fessler, JH, Hudson, BG

Nat. Chem. Biol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peroxidase activity of PXDN:Br- [extracellular region]
Physical Entity
Activity
Orthologous Events
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Created