Reactome | Negative regulation by 'PTPN11 [cytosol]'

Negative regulation by 'PTPN11 [cytosol]'

Stable Identifier

R-HSA-2569047

Type

NegativeRegulation

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
        
        PTPN11 [cytosol]

Regulation participants

Regulation type

NegativeRegulation

Regulated entity

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4

Regulator

PTPN11 [cytosol]

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