Reactome | p-T288-AURKA [cytosol]

p-T288-AURKA [cytosol]

Stable Identifier

R-HSA-2574832

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AURKA phosphorylates TP53 (Homo sapiens)
        
        p-T288-AURKA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14965 AURKA

Gene Names

AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6

Chain

chain:1-403

Reference Genes

BioGPS Gene:6790 AURKA

COSMIC (genes):AURKA AURKA

CTD Gene:6790 AURKA

dbSNP Gene:6790 AURKA

ENSEMBL:ENSG00000087586 AURKA

HGNC:11393 AURKA

KEGG Gene (Homo sapiens):6790 AURKA

Monarch:6790 AURKA

NCBI Gene:6790 AURKA

OMIM:603072 AURKA

UCSC:O14965 AURKA

Reference Transcript

Other Identifiers

0003140707

04150+2.7.11.1

04151+2.7.11.1

04714+2.7.11.1

04926+2.7.11.1

05163+2.7.11.1

05165+2.7.11.1

05170+2.7.11.1

11718943_a_at

11751206_s_at

1454

16920548

204092_s_at

208079_s_at

2456937

2456940

2456941

2456943

2456944

2636

3265227

3265230

34851_at

34852_g_at

3910786

3910787

3910788

3910789

3910790

3910791

3910796

3910797

3910800

3910802

3910803

3910804

3910805

3910806

3910807

3910808

6790

8067167

A3KFJ0

A3KFJ1

A3KFJ2

A_23_P131866

AURKA

AURKA-201

AURKA-202

AURKA-203

AURKA-205

AURKA-206

AURKA-207

AURKA-208

CAB001454

CCDS13451

ENSG00000087586

ENSP00000216911

ENSP00000321591

ENSP00000360407

ENSP00000379247

ENSP00000379249

ENSP00000379250

ENSP00000379251

ENST00000312783

ENST00000312783.10

ENST00000347343

ENST00000347343.6

ENST00000371356

ENST00000371356.6

ENST00000395911

ENST00000395911.5

ENST00000395913

ENST00000395913.7

ENST00000395914

ENST00000395914.5

ENST00000395915

ENST00000395915.7

EntrezGene:6790

EntrezGene:AURKA

g4507274_3p_s_at

GE54110

GO:0000003

GO:0000086

GO:0000166

GO:0000212

GO:0000226

GO:0000228

GO:0000278

GO:0000780

GO:0000902

GO:0000922

GO:0003674

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0005929

GO:0006464

GO:0006468

GO:0006511

GO:0006950

GO:0006977

GO:0007010

GO:0007049

GO:0007051

GO:0007052

GO:0007057

GO:0007098

GO:0007100

GO:0007165

GO:0008150

GO:0008219

GO:0009056

GO:0009611

GO:0009948

GO:0010389

GO:0010972

GO:0015630

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019901

GO:0021700

GO:0022607

GO:0030030

GO:0030154

GO:0030496

GO:0031145

GO:0031616

GO:0031625

GO:0031647

GO:0032091

GO:0032133

GO:0032436

GO:0032465

GO:0032991

GO:0035174

GO:0035404

GO:0040007

GO:0042585

GO:0042995

GO:0043066

GO:0043167

GO:0043203

GO:0043226

GO:0045120

GO:0045840

GO:0046605

GO:0046777

GO:0046982

GO:0048471

GO:0048856

GO:0051233

GO:0051276

GO:0051301

GO:0051321

GO:0051642

GO:0071539

GO:0072686

GO:0072687

GO:0097421

GO:0097431

GO:0140014

GO:1900195

GO:1901796

GO:1990138

HGNC:11393

HPA002636

ILMN_1680955

ILMN_2357438

IPR000719

IPR008271

IPR011009

IPR017441

IPR030611

IPR030616

MIM:603072

NM_001323303

NM_001323304

NM_001323305

NM_003600

NM_198433

NM_198434

NM_198435

NM_198436

NM_198437

NP_001310232

NP_001310233

NP_001310234

NP_003591

NP_940835

NP_940836

NP_940837

NP_940838

NP_940839

PF00069

PH_hs_0013285

Q5QPD1

Q5QPD2

Q5QPD4

SM00220

TC20000968.hg

TC20001661.hg

UPI000013C70F

XM_017028034

XM_017028035

XM_024451974

XP_016883523

XP_016883524

XP_024307742

Participant Of

hasComponent

Centrosome:p-T288-AURKA [cytosol]

Other forms of this molecule

SUMO1-K258-AURKA [cytosol]

AURKA [nucleoplasm]

p-T288-AURKA [nucleoplasm]

PolyUb-AURKA [cytosol]

AURKA [cytosol]

Inferred To

phospho-p-T288-AURKA [cytosol] (Bos taurus)

phospho-p-T288-AURKA [cytosol] (Canis familiaris)

phospho-p-T288-AURKA [cytosol] (Danio rerio)

phospho-p-T288-AURKA [cytosol] (Gallus gallus)

phospho-p-T288-AURKA [cytosol] (Mus musculus)

phospho-p-T288-AURKA [cytosol] (Rattus norvegicus)

phospho-p-T288-AURKA [cytosol] (Sus scrofa)

phospho-p-T288-AURKA [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 288

Coordinate

288

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001310233.1, NP_940839.1, NP_940837.1, NP_940835.1, XP_016883524.1, NP_940838.1, NP_940836.1, NP_003591.2, NP_001310232.1, NP_001310234.1

ZINC - World Drugs

AURKA_HUMAN

OpenTargets

ENSG00000087586

ZINC - FDA approved

AURKA_HUMAN

ZINC - Substances

AURKA_HUMAN

ZINC target

O14965

ZINC - Biogenic

AURKA_HUMAN

PRO

O14965

PDB

5OS3, 3K5U, 2C6E, 5OS4, 5ONE, 6R4B, 4DEB, 3MYG, 4BYI, 5DN3, 5OSD, 6R4A, 4J8M, 5ORZ, 2W1C, 5OSE, 2W1G, 2BMC, 2W1D, 4BN1, 3UOK, 3UNZ, 4UZH, 3H0Z, 6GRA, 5LXM, 5OS0, 1MUO, 5EW9, 2X6D, 3H0Y, 5DR9, 5DR2, 3FDN, 3LAU, 5AAE, 2X6E, 5ORV, 4DEA, 4JBP, 5ORW, 6HJK, 5AAF, 5DT4, 5ORS, 3W2C, 4JBQ, 1MQ4, 4JAJ, 5ORT, 5AAD, 3HA6, 1OL7, 3UOD, 3R22, 5DT3, 2J50, 3UOJ, 6CPG, 5ORN, 2X81, 5AAG, 6CPF, 5DPV, 5ORO, 3QBN, 5G1X, 2DWB, 4ZTS, 5OBR, 2NP8, 3W16, 4C3R, 6R4C, 5OSF, 4DED, 2W1F, 2WTV, 4ZTQ, 2XRU, 3P9J, 5OBJ, 4O0W, 5OS1, 2C6D, 3W18, 3R21, 6C2R, 5OS2, 4UYN, 6C2T, 5DRD, 3VAP, 4DEE, 4JBO, 3M11, 3O51, 5ODT, 2XNG, 2W1E, 4O0S, 5ORX, 5L8J, 3UOH, 5ORY, 5G15, 4PRJ, 3EFW, 3UO6, 4O0U, 4DHF, 4UZD, 4CEG, 5DR6, 3UP2, 5L8L, 6HJJ, 4C3P, 4ZS0, 2WQE, 3W10, 1OL5, 3E5A, 5DOS, 3NRM, 1OL6, 5DT0, 4BYJ, 5ORP, 5ZAN, 2WTW, 5L8K, 5ORR, 3UOL, 3O50, 3COH, 6R49, 2XNE, 3H10, 4B0G, 4J8N, 5OS5, 4ZTR, 3UO5, 3UP7, 4JAI, 5DNR, 3UO4, 5OS6, 6CPE, 6C83, 2J4Z, 6R4D, 5ORL

ZINC - Investigational

AURKA_HUMAN

ZINC - Metabolites

AURKA_HUMAN

IntEnz

2.7.11.1

GeneCards

O14965

ZINC - Predictions - Purchasable

AURKA_HUMAN

HMDB Protein

HMDBP01317

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.85	8
UniProt:P04198 MYCN			0.846	12
UniProt:O15350 TP73	3	TP73 [cytosol] (R-HSA-8957239) PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [nucleoplasm] (R-HSA-6798094)	0.632	11
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.602	4
UniProt:Q8VDQ8 SIR2			0.599	5
UniProt:Q8TEP8 CEP192	1	CEP192 [cytosol] (R-HSA-380319)	0.564	2
UniProt:Q9NQS7-1 INCENP			0.558	2
ChEBI:83432 CD532			0.558	2
UniProt:O14920 IKBKB	3	p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB [cytosol] (R-HSA-168114) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.544	2
UniProt:P23468 PTPRD	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.544	2
UniProt:Q16659 MAPK6	6	MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344)	0.525	2
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.525	4
UniProt:Q9NWT8 AURKAIP1	1	AURKAIP1 [mitochondrial inner membrane] (R-HSA-5368203)	0.524	2
UniProt:Q13123 RED			0.524	3
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.524	2
UniProt:Q96R06 SPAG5			0.508	3
UniProt:Q9NQS7 INCENP	2	INCENP [cytosol] (R-HSA-375311) INCENP [nucleoplasm] (R-HSA-4655393)	0.499	2
UniProt:P06748 NPM1	5	p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [cytosol] (R-HSA-3008211) NPM1 [nucleoplasm] (R-HSA-606320) SUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) SUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.489	3
UniProt:Q922D4	1	PPP6R3 [cytosol] (R-MMU-5685722)	0.462	3