Reactome | p-T288-AURKA [cytosol]

p-T288-AURKA [cytosol]

Stable Identifier

R-HSA-2574832

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AURKA phosphorylates TP53 (Homo sapiens)
        
        p-T288-AURKA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14965 AURKA

Gene Names

AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6

Chain

chain:1-403

Reference Genes

BioGPS Gene:6790 AURKA

COSMIC (genes):AURKA AURKA

CTD Gene:6790 AURKA

dbSNP Gene:6790 AURKA

ENSEMBL:ENSG00000087586 AURKA

HGNC:11393 AURKA

KEGG Gene (Homo sapiens):6790 AURKA

Monarch:6790 AURKA

NCBI Gene:6790 AURKA

OMIM:603072 AURKA

UCSC:O14965 AURKA

Reference Transcript

Other Identifiers

0003140707

11718943_a_at

11751206_s_at

16920548

204092_PM_s_at

204092_s_at

208079_PM_s_at

208079_s_at

2456937

2456940

2456941

2456943

2456944

3265227

3265230

34851_at

34852_g_at

3910786

3910787

3910788

3910789

3910790

3910791

3910796

3910797

3910800

3910802

3910803

3910804

3910805

3910806

3910807

3910808

6790

8067167

A_23_P131866

GE54110

GO:0000003

GO:0000086

GO:0000166

GO:0000212

GO:0000226

GO:0000278

GO:0000902

GO:0000922

GO:0003674

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0005929

GO:0006464

GO:0006468

GO:0006950

GO:0007005

GO:0007010

GO:0007049

GO:0007051

GO:0007052

GO:0007057

GO:0007098

GO:0007100

GO:0007165

GO:0008150

GO:0008219

GO:0009056

GO:0009611

GO:0009948

GO:0010389

GO:0010629

GO:0015630

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0021700

GO:0022607

GO:0030030

GO:0030154

GO:0030496

GO:0031616

GO:0031625

GO:0031647

GO:0032091

GO:0032133

GO:0032436

GO:0032465

GO:0032991

GO:0035174

GO:0035404

GO:0040007

GO:0042585

GO:0042995

GO:0043005

GO:0043066

GO:0043167

GO:0043203

GO:0043226

GO:0045120

GO:0045840

GO:0046605

GO:0046777

GO:0046982

GO:0048471

GO:0048856

GO:0051233

GO:0051276

GO:0051301

GO:0051321

GO:0051642

GO:0071539

GO:0072686

GO:0072687

GO:0090141

GO:0097421

GO:0097431

GO:0106310

GO:0140014

GO:1900195

GO:1901796

GO:1990138

HMNXSV003001259

ILMN_1680955

ILMN_2357438

PH_hs_0013285

TC20000968.hg

TC20001661.hg

g4507274_3p_s_at

Participates

as a component of

Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)

Other forms of this molecule

SUMO1-K258-AURKA [cytosol]

AURKA [nucleoplasm]

p-T288-AURKA [nucleoplasm]

PolyUb-AURKA [cytosol]

AURKA [cytosol]

Inferred To

phospho-aurka [cytosol] (Danio rerio)

phospho-aurka [cytosol] (Xenopus tropicalis)

phospho-AURKA [cytosol] (Bos taurus)

phospho-AURKA [cytosol] (Canis familiaris)

phospho-AURKA [cytosol] (Sus scrofa)

phospho-AURKB [cytosol] (Gallus gallus)

phospho-Aurka [cytosol] (Mus musculus)

phospho-Aurka [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 288

Coordinate

288

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_940837.1, NP_940839.1, NP_001310232.1, NP_001310233.1, NP_940835.1, NP_001310234.1, NP_940838.1, NP_940836.1, NP_003591.2, XP_016883524.1

ZINC - World Drugs

AURKA_HUMAN

Guide to Pharmacology - Targets

1936

OpenTargets

ENSG00000087586

ZINC - FDA approved

AURKA_HUMAN

ZINC - Substances

AURKA_HUMAN

ZINC - Biogenic

AURKA_HUMAN

ZINC target

O14965

PRO

O14965

PDB

6GRA, 2BMC, 2C6E, 3MYG, 4BN1, 6I2U, 3UO5, 5AAG, 4UYN, 7O2V, 3UO6, 4C3R, 5DOS, 5ONE, 6CPF, 4ZTQ, 2WTV, 3FDN, 3M11, 3UOD, 3K5U, 3O50, 5OS0, 6R49, 3LAU, 2XNG, 5DR6, 3R22, 5AAD, 7AYH, 2W1C, 5OS5, 5ORT, 2WQE, 5ORV, 5DT0, 5G1X, 5OS6, 4O0S, 3VAP, 3H0Y, 4DED, 4B0G, 4C3P, 4JBP, 5ORP, 6R4C, 4JAI, 4O0U, 3UO4, 3NRM, 1OL7, 4ZS0, 5ORZ, 5OSE, 5ORO, 2DWB, 5L8L, 2WTW, 5DR9, 4J8N, 2XNE, 5DN3, 5ORX, 6CPG, 5ORY, 6HJK, 4ZTR, 2X6D, 3QBN, 6VPL, 5DT3, 5DPV, 4PRJ, 6Z4Y, 5ORW, 3H0Z, 2J50, 2W1E, 5OSF, 5OS3, 3P9J, 2W1G, 3W18, 2C6D, 1MQ4, 4JBQ, 2NP8, 6R4A, 5DR2, 5OSD, 4BYI, 5OS1, 5ZAN, 5OS2, 3EFW, 6CPE, 3HA6, 4DHF, 5DT4, 2X6E, 3H10, 2W1D, 2XRU, 3E5A, 7AYI, 6XKA, 5L8J, 6R4B, 1OL5, 6HJJ, 5AAE, 2J4Z, 5DRD, 4ZTS, 6VPI, 5ORR, 6R4D, 6VPH, 3UNZ, 5OS4, 5EW9, 4JAJ, 5AAF, 5ORN, 6C2R, 6VPG, 4DEE, 5OBJ, 2X81, 4O0W, 5DNR, 3UP2, 4BYJ, 5L8K, 3W10, 5ODT, 1MUO, 5OBR, 3COH, 5ORL, 3UP7, 3R21, 4J8M, 3O51, 5LXM, 4CEG, 3W16, 4JBO, 6VPJ, 5ORS, 3UOJ, 6VPM, 3W2C, 6C83, 3UOH, 4UZD, 5G15, 2W1F, 4UZH, 1OL6, 6C2T, 4DEA, 3UOL, 4DEB, 3UOK

ZINC - Investigational

AURKA_HUMAN

ZINC - Metabolites

AURKA_HUMAN

GeneCards

O14965

HPA

ENSG00000087586-AURKA

Ensembl

ENST00000312783, ENSP00000379247, ENSP00000379249, ENSG00000087586, ENSP00000360407, ENSP00000216911, ENSP00000379251, ENSP00000379250, ENST00000371356, ENST00000347343, ENST00000395913, ENST00000395915, ENST00000395911, ENST00000395914, ENSP00000321591

Pharos - Targets

O14965

ZINC - Predictions - Purchasable

AURKA_HUMAN

HMDB Protein

HMDBP01317

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.85	8
UniProt:P04198 MYCN	1	MYCN [nucleoplasm] (R-HSA-452357)	0.834	12
UniProt:Q8TEP8 CEP192	1	CEP192 [cytosol] (R-HSA-380319)	0.669	3
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.632	11
UniProt:Q8VDQ8	1	Sirt2 [cytosol] (R-MMU-2161118)	0.599	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.581	4
UniProt:Q9NQS7-1 INCENP			0.558	2
ChEBI:83432 CD532			0.558	2
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.544	2
UniProt:P23468 PTPRD	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.544	2
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.527	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:Q16659 MAPK6	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.527	2
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.525	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.525	4
UniProt:Q9NWT8 AURKAIP1	1	AURKAIP1 [mitochondrial inner membrane] (R-HSA-5368203)	0.524	2
UniProt:Q13123 RED			0.524	3
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.524	2
UniProt:Q96R06 SPAG5			0.508	3
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.499	2
UniProt:P06748 NPM1	10	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y ALK(1068-1620) fusion [cytosol] (R-HSA-9730703)	0.489	3

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