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p-T288-AURKA [cytosol]
Stable Identifier
R-HSA-2574832
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
AURKA Activation by TPX2 (Homo sapiens)
TPX2 promotes AURKA autophosphorylation (Homo sapiens)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
AJUBA facilitates AURKA autophosphorylation (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
AURKA phosphorylates PLK1 (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AURKA phosphorylates TP53 (Homo sapiens)
p-T288-AURKA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14965 AURKA
Gene Names
AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Chain
chain:1-403
Reference Genes
BioGPS Gene:6790 AURKA
COSMIC (genes):AURKA AURKA
CTD Gene:6790 AURKA
dbSNP Gene:6790 AURKA
ENSEMBL:ENSG00000087586 AURKA
HGNC:11393 AURKA
KEGG Gene (Homo sapiens):6790 AURKA
Monarch:6790 AURKA
NCBI Gene:6790 AURKA
OMIM:603072 AURKA
UCSC:O14965 AURKA
Reference Transcript
RefSeq:NM_198437.2 AURKA
RefSeq:NM_003600.3 AURKA
RefSeq:XM_017028035.1 AURKA
RefSeq:NM_001323303.1 AURKA
RefSeq:NM_198433.2 AURKA
RefSeq:NM_001323304.1 AURKA
RefSeq:NM_198434.2 AURKA
RefSeq:NM_198436.2 AURKA
RefSeq:NM_001323305.1 AURKA
RefSeq:NM_198435.2 AURKA
Other Identifiers
0003140707
11718943_a_at
11751206_s_at
16920548
204092_PM_s_at
204092_s_at
208079_PM_s_at
208079_s_at
2456937
2456940
2456941
2456943
2456944
3265227
3265230
34851_at
34852_g_at
3910786
3910787
3910788
3910789
3910790
3910791
3910796
3910797
3910800
3910802
3910803
3910804
3910805
3910806
3910807
3910808
6790
8067167
A_23_P131866
GE54110
GO:0000003
GO:0000086
GO:0000166
GO:0000212
GO:0000226
GO:0000278
GO:0000902
GO:0000922
GO:0003674
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005876
GO:0005929
GO:0006464
GO:0006468
GO:0006950
GO:0007005
GO:0007010
GO:0007049
GO:0007051
GO:0007052
GO:0007057
GO:0007098
GO:0007100
GO:0007165
GO:0008150
GO:0008219
GO:0009056
GO:0009611
GO:0009948
GO:0010389
GO:0010629
GO:0015630
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0019901
GO:0021700
GO:0022607
GO:0030030
GO:0030154
GO:0030496
GO:0031616
GO:0031625
GO:0031647
GO:0032091
GO:0032133
GO:0032436
GO:0032465
GO:0032991
GO:0035174
GO:0035404
GO:0040007
GO:0042585
GO:0042995
GO:0043005
GO:0043066
GO:0043167
GO:0043203
GO:0043226
GO:0045120
GO:0045840
GO:0046605
GO:0046777
GO:0046982
GO:0048471
GO:0048856
GO:0051233
GO:0051276
GO:0051301
GO:0051321
GO:0051642
GO:0071539
GO:0072686
GO:0072687
GO:0090141
GO:0097421
GO:0097431
GO:0106310
GO:0140014
GO:1900195
GO:1901796
GO:1990138
HMNXSV003001259
ILMN_1680955
ILMN_2357438
PH_hs_0013285
TC20000968.hg
TC20001661.hg
g4507274_3p_s_at
Participates
as a component of
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
Other forms of this molecule
SUMO1-K258-AURKA [cytosol]
AURKA [nucleoplasm]
p-T288-AURKA [nucleoplasm]
PolyUb-AURKA [cytosol]
AURKA [cytosol]
Inferred To
phospho-aurka [cytosol]
(Danio rerio)
phospho-aurka [cytosol]
(Xenopus tropicalis)
phospho-AURKA [cytosol]
(Bos taurus)
phospho-AURKA [cytosol]
(Canis familiaris)
phospho-AURKA [cytosol]
(Sus scrofa)
phospho-AURKB [cytosol]
(Gallus gallus)
phospho-Aurka [cytosol]
(Mus musculus)
phospho-Aurka [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 288
Coordinate
288
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_940837.1
,
NP_940839.1
,
NP_001310232.1
,
NP_001310233.1
,
NP_940835.1
,
NP_001310234.1
,
NP_940838.1
,
NP_940836.1
,
NP_003591.2
,
XP_016883524.1
ZINC - World Drugs
AURKA_HUMAN
Guide to Pharmacology - Targets
1936
OpenTargets
ENSG00000087586
ZINC - FDA approved
AURKA_HUMAN
ZINC - Substances
AURKA_HUMAN
ZINC - Biogenic
AURKA_HUMAN
ZINC target
O14965
PRO
O14965
PDB
6GRA
,
2BMC
,
2C6E
,
3MYG
,
4BN1
,
6I2U
,
3UO5
,
5AAG
,
4UYN
,
7O2V
,
3UO6
,
4C3R
,
5DOS
,
5ONE
,
6CPF
,
4ZTQ
,
2WTV
,
3FDN
,
3M11
,
3UOD
,
3K5U
,
3O50
,
5OS0
,
6R49
,
3LAU
,
2XNG
,
5DR6
,
3R22
,
5AAD
,
7AYH
,
2W1C
,
5OS5
,
5ORT
,
2WQE
,
5ORV
,
5DT0
,
5G1X
,
5OS6
,
4O0S
,
3VAP
,
3H0Y
,
4DED
,
4B0G
,
4C3P
,
4JBP
,
5ORP
,
6R4C
,
4JAI
,
4O0U
,
3UO4
,
3NRM
,
1OL7
,
4ZS0
,
5ORZ
,
5OSE
,
5ORO
,
2DWB
,
5L8L
,
2WTW
,
5DR9
,
4J8N
,
2XNE
,
5DN3
,
5ORX
,
6CPG
,
5ORY
,
6HJK
,
4ZTR
,
2X6D
,
3QBN
,
6VPL
,
5DT3
,
5DPV
,
4PRJ
,
6Z4Y
,
5ORW
,
3H0Z
,
2J50
,
2W1E
,
5OSF
,
5OS3
,
3P9J
,
2W1G
,
3W18
,
2C6D
,
1MQ4
,
4JBQ
,
2NP8
,
6R4A
,
5DR2
,
5OSD
,
4BYI
,
5OS1
,
5ZAN
,
5OS2
,
3EFW
,
6CPE
,
3HA6
,
4DHF
,
5DT4
,
2X6E
,
3H10
,
2W1D
,
2XRU
,
3E5A
,
7AYI
,
6XKA
,
5L8J
,
6R4B
,
1OL5
,
6HJJ
,
5AAE
,
2J4Z
,
5DRD
,
4ZTS
,
6VPI
,
5ORR
,
6R4D
,
6VPH
,
3UNZ
,
5OS4
,
5EW9
,
4JAJ
,
5AAF
,
5ORN
,
6C2R
,
6VPG
,
4DEE
,
5OBJ
,
2X81
,
4O0W
,
5DNR
,
3UP2
,
4BYJ
,
5L8K
,
3W10
,
5ODT
,
1MUO
,
5OBR
,
3COH
,
5ORL
,
3UP7
,
3R21
,
4J8M
,
3O51
,
5LXM
,
4CEG
,
3W16
,
4JBO
,
6VPJ
,
5ORS
,
3UOJ
,
6VPM
,
3W2C
,
6C83
,
3UOH
,
4UZD
,
5G15
,
2W1F
,
4UZH
,
1OL6
,
6C2T
,
4DEA
,
3UOL
,
4DEB
,
3UOK
ZINC - Investigational
AURKA_HUMAN
ZINC - Metabolites
AURKA_HUMAN
GeneCards
O14965
HPA
ENSG00000087586-AURKA
Ensembl
ENST00000312783
,
ENSP00000379247
,
ENSP00000379249
,
ENSG00000087586
,
ENSP00000360407
,
ENSP00000216911
,
ENSP00000379251
,
ENSP00000379250
,
ENST00000371356
,
ENST00000347343
,
ENST00000395913
,
ENST00000395915
,
ENST00000395911
,
ENST00000395914
,
ENSP00000321591
Pharos - Targets
O14965
ZINC - Predictions - Purchasable
AURKA_HUMAN
HMDB Protein
HMDBP01317
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.85
8
UniProt:P04198 MYCN
1
MYCN [nucleoplasm]
(R-HSA-452357)
0.834
12
UniProt:Q8TEP8 CEP192
1
CEP192 [cytosol]
(R-HSA-380319)
0.669
3
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.632
11
UniProt:Q8VDQ8
1
Sirt2 [cytosol]
(R-MMU-2161118)
0.599
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.581
4
UniProt:Q9NQS7-1 INCENP
0.558
2
ChEBI:83432 CD532
0.558
2
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.544
2
UniProt:P23468 PTPRD
1
PTPRD [plasma membrane]
(R-HSA-6797868)
0.544
2
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.527
2
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.527
2
UniProt:Q16659 MAPK6
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.527
2
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.525
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.525
4
UniProt:Q9NWT8 AURKAIP1
1
AURKAIP1 [mitochondrial inner membrane]
(R-HSA-5368203)
0.524
2
UniProt:Q13123 RED
0.524
3
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.524
2
UniProt:Q96R06 SPAG5
0.508
3
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.499
2
UniProt:P06748 NPM1
10
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
0.489
3
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