AJUBA facilitates AURKA autophosphorylation

Stable Identifier
R-HSA-2574840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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AURKA (Aurora A kinase) activation through autophosphorylation of threonine T288 is facilitated by AJUBA binding. AJUBA is also phosphorylated by AURKA on an unidentified serine or threonine residue (Hirota et al. 2003).
Literature References
PubMed ID Title Journal Year
13678582 Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

Hirota, T, Hatakeyama, K, Nitta, M, Sasayama, T, Saya, H, Kunitoku, N, Zhang, D, Marumoto, T

Cell 2003
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Centrosome:AURKA:AJUBA [cytosol]

Orthologous Events
Authored
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Created
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