Reactome | Translocation of COP1 from the nucleus to the cytoplasm

Translocation of COP1 from the nucleus to the cytoplasm

Stable Identifier

R-HSA-264418

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
        
        Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)

General

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Translocation of COP1 from the nucleus to the cytoplasm

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Ionizing radiation results in an ATM-dependent movement of COP1 from the nucleus to the cytoplasm (Dornan et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
16931761	ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage Dixit, VM, Shimizu, H, O'Rourke, K, Eby, M, Dornan, D, Dudhela, T, Mah, A, Seshagiri, S	Science	2006