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CDK1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-264424
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cdc2
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
CDK1 phosphorylates VCPIP1 (Homo sapiens)
CDK1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06493 CDK1
Gene Names
CDK1, CDC2, CDC28A, CDKN1, P34CDC2
Chain
chain:1-297
Reference Genes
BioGPS Gene:983 CDK1
COSMIC (genes):CDK1 CDK1
CTD Gene:983 CDK1
dbSNP Gene:983 CDK1
ENSEMBL:ENSG00000170312 CDK1
HGNC:1722 CDK1
KEGG Gene (Homo sapiens):983 CDK1
Monarch:983 CDK1
NCBI Gene:983 CDK1
OMIM:116940 CDK1
UCSC:P06493 CDK1
Reference Transcript
RefSeq:NM_001786.4 CDK1
RefSeq:NM_033379.4 CDK1
RefSeq:XM_005270303.3 CDK1
RefSeq:NM_001320918.1 CDK1
Other Identifiers
0001660059
0005360092
11726617_s_at
11745843_a_at
16705159
1803_at
203213_at
203214_x_at
210559_s_at
3248301
3248302
3248303
3248306
3248307
3248308
3248309
3248310
3248314
3248315
3248316
3248318
3248319
3248320
3248322
33324_s_at
40915_r_at
7927710
91194_at
983
A_23_P138507
GE63002
GO:0000003
GO:0000086
GO:0000166
GO:0000187
GO:0000226
GO:0000228
GO:0000278
GO:0000307
GO:0000784
GO:0001618
GO:0003674
GO:0003682
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005759
GO:0005789
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006091
GO:0006259
GO:0006260
GO:0006281
GO:0006367
GO:0006464
GO:0006468
GO:0006810
GO:0006913
GO:0006915
GO:0006950
GO:0006977
GO:0007010
GO:0007049
GO:0007077
GO:0007095
GO:0007098
GO:0007165
GO:0007344
GO:0007568
GO:0007569
GO:0008150
GO:0008219
GO:0008283
GO:0008353
GO:0009056
GO:0009058
GO:0009636
GO:0009790
GO:0010243
GO:0010389
GO:0010628
GO:0010971
GO:0014038
GO:0014070
GO:0014075
GO:0014823
GO:0015031
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016477
GO:0016572
GO:0016579
GO:0016740
GO:0018105
GO:0018107
GO:0022607
GO:0030154
GO:0030261
GO:0030332
GO:0030496
GO:0030544
GO:0030855
GO:0031100
GO:0031145
GO:0032991
GO:0034501
GO:0034641
GO:0035173
GO:0040007
GO:0040011
GO:0042307
GO:0042493
GO:0042542
GO:0042752
GO:0043066
GO:0043167
GO:0043226
GO:0044403
GO:0044772
GO:0045471
GO:0045740
GO:0045931
GO:0045995
GO:0046686
GO:0046688
GO:0046718
GO:0048511
GO:0048678
GO:0048856
GO:0048870
GO:0051276
GO:0051301
GO:0055015
GO:0060045
GO:0061024
GO:0065003
GO:0070062
GO:0070301
GO:0072686
GO:0090166
GO:0097125
GO:0097472
GO:0097711
GO:1900182
GO:1901990
GO:1905448
Hs.184572.0.S2_3p_at
ILMN_1710428
ILMN_1747911
PH_hs_0016443
TC10000373.hg
X05360_at
g3126638_3p_a_at
Other forms of this molecule
CDK1 [nucleoplasm]
CDK1 [cytosol]
p-T161-CDK1 [nucleoplasm]
p-T161-CDK1 [cytosol]
p-T14,Y15,T161-CDK1 [cytosol]
p-T14-CDK1 [cytosol]
p-T14-CDK1 [nucleoplasm]
p-T14,Y15,T161-CDK1 [nucleoplasm]
p-T14,T161-CDK1 [nucleoplasm]
Inferred To
CDC2 [endoplasmic reticulum membrane] (Sus scrofa)
CDK1 [endoplasmic reticulum membrane] (Canis familiaris)
CDK1 [endoplasmic reticulum membrane] (Gallus gallus)
CDK1 [endoplasmic reticulum membrane] (Xenopus tropicalis)
Cdk1 [endoplasmic reticulum membrane] (Mus musculus)
Cdk1 [endoplasmic reticulum membrane] (Rattus norvegicus)
cdk1 [endoplasmic reticulum membrane] (Danio rerio)
Cross References
RefSeq
NP_203698.1
,
NP_001307847.1
,
XP_005270360.1
,
NP_001777.1
ZINC - World Drugs
CDK1_HUMAN
OpenTargets
ENSG00000170312
ZINC - Substances
CDK1_HUMAN
ZINC target
P06493
ZINC - Biogenic
CDK1_HUMAN
PRO
P06493
PDB
4YC6
,
6GU7
,
6GU4
,
1LC9
,
6GU6
,
6GU2
,
5LQF
,
6GU3
,
4Y72
,
4YC3
,
5HQ0
ZINC - Investigational
CDK1_HUMAN
ZINC - Metabolites
CDK1_HUMAN
IntEnz
2.7.11.22
GeneCards
P06493
HPA
ENSG00000170312-CDK1
Ensembl
ENST00000373809
,
ENSP00000362915
,
ENSP00000378699
,
ENST00000395284
,
ENSP00000325970
,
ENSG00000170312
,
ENST00000316629
ZINC - Predictions - Purchasable
CDK1_HUMAN
HMDB Protein
HMDBP01364
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14635 CCNB1
4
CCNB1 [cytosol]
(R-HSA-157451)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
0.969
22
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.86
9
UniProt:P38936 CDKN1A
5
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
CDKN1A [cytosol]
(R-HSA-182512)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
0.798
5
UniProt:Q99640 PKMYT1
3
PKMYT1 [nucleoplasm]
(R-HSA-74386)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [cytosol]
(R-HSA-157457)
0.759
5
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.725
6
UniProt:P33552 CKS2
0.725
5
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.725
4
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.667
3
UniProt:Q12778 FOXO1
5
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
p-S215 FOXO1 [nucleoplasm]
(R-HSA-5692651)
0.645
5
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.643
3
UniProt:O95835 LATS1
2
p-S909,T1097-LATS1 [cytosol]
(R-HSA-2028551)
LATS1 [cytosol]
(R-HSA-2028562)
0.632
3
UniProt:O43508 TNFSF12
2
sTNFSF12 [extracellular region]
(R-HSA-5675974)
TNFSF12 [plasma membrane]
(R-HSA-5667154)
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q16667 CDKN3
0.553
2
UniProt:Q9H211 CDT1
2
CDT1 [nucleoplasm]
(R-HSA-68536)
CDT1 [cytosol]
(R-HSA-113788)
0.527
2
UniProt:P24385 CCND1
4
CCND1 [cytosol]
(R-HSA-68328)
CCND1 [nucleoplasm]
(R-HSA-113832)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.527
2
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
0.527
3
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.527
2
UniProt:Q99741 CDC6
4
p-CDC6 [cytosol]
(R-HSA-68583)
CDC6 [cytosol]
(R-HSA-113566)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
CDC6 [nucleoplasm]
(R-HSA-68542)
0.524
2
UniProt:P36957 DLST
2
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.499
3
UniProt:O75618-1 DEDD
0.499
2
UniProt:P30307 CDC25C
8
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
CDC25C [cytosol]
(R-HSA-157879)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
CDC25C [nucleoplasm]
(R-HSA-69741)
0.499
2
UniProt:P21796 VDAC1
4
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
0.499
3
UniProt:Q86V81 ALYREF
2
ALYREF [cytosol]
(R-HSA-158482)
ALYREF [nucleoplasm]
(R-HSA-156649)
0.499
4
UniProt:P01732 CD8A
1
CD8A [plasma membrane]
(R-HSA-197601)
0.488
2
UniProt:Q96GD4 AURKB
3
AURKB [nucleoplasm]
(R-HSA-4655360)
SUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [cytosol]
(R-HSA-174231)
0.463
5
UniProt:O15392 BIRC5
3
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [cytosol]
(R-HSA-50851)
0.463
6
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.463
2
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