Reactome | ARRB1 [cytosol]

ARRB1 [cytosol]

Stable Identifier

R-HSA-264470

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Beta-arrestin-1, ARRB1_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
        
        USP33:CCP110,ARRB1,ARRB2 [cytosol] (Homo sapiens)
        
        CCP110,ARRB2,(ARRB1) [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - ARRB bind GPCRs (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB [cytosol] (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
    - Lysosome Vesicle Biogenesis (Homo sapiens)
      - Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
        
        ARRB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49407 ARRB1

Gene Names

ARRB1, ARR1

Chain

chain:1-418

Reference Genes

BioGPS Gene:408 ARRB1

COSMIC (genes):ARRB1 ARRB1

CTD Gene:408 ARRB1

dbSNP Gene:408 ARRB1

ENSEMBL:ENSG00000137486 ARRB1

HGNC:711 ARRB1

KEGG Gene (Homo sapiens):408 ARRB1

Monarch:408 ARRB1

NCBI Gene:408 ARRB1

OMIM:107940 ARRB1

UCSC:P49407 ARRB1

Reference Transcript

Other Identifiers

0002190270

11742838_at

11760185_s_at

16742202

218832_x_at

221861_at

222756_s_at

222912_at

228444_at

3382217

3382218

3382219

3382220

3382221

3382222

3382224

3382225

3382230

3382231

3382233

3382234

3382236

3382239

3382241

3382243

3382246

3382247

3382252

3382278

3382279

3382280

408

43511_s_at

49111_at

58259_at

59336_at

7950473

A_23_P203702

A_24_P386622

GE54737

GE87006

GO:0000003

GO:0000139

GO:0000187

GO:0000785

GO:0001664

GO:0001933

GO:0001934

GO:0002031

GO:0002092

GO:0003674

GO:0003713

GO:0004857

GO:0005096

GO:0005102

GO:0005159

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0005905

GO:0006355

GO:0006357

GO:0006464

GO:0006511

GO:0006810

GO:0006897

GO:0006915

GO:0006950

GO:0007010

GO:0007165

GO:0007186

GO:0007267

GO:0007602

GO:0008134

GO:0008150

GO:0008219

GO:0008277

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009968

GO:0014069

GO:0015031

GO:0016020

GO:0016192

GO:0016323

GO:0016567

GO:0016573

GO:0016604

GO:0019899

GO:0022607

GO:0030168

GO:0030234

GO:0030276

GO:0030331

GO:0030659

GO:0031143

GO:0031397

GO:0031398

GO:0031410

GO:0031434

GO:0031625

GO:0031691

GO:0031692

GO:0031701

GO:0031762

GO:0031896

GO:0032088

GO:0032092

GO:0032715

GO:0032717

GO:0033138

GO:0034260

GO:0034393

GO:0034641

GO:0035025

GO:0035066

GO:0035612

GO:0035615

GO:0035774

GO:0042493

GO:0042592

GO:0042699

GO:0042981

GO:0042995

GO:0043027

GO:0043066

GO:0043149

GO:0043154

GO:0043161

GO:0043197

GO:0043226

GO:0043280

GO:0043524

GO:0043547

GO:0044325

GO:0045211

GO:0045309

GO:0045746

GO:0045944

GO:0048856

GO:0051219

GO:0051276

GO:0061024

GO:0070373

GO:0070374

GO:0090240

GO:1990763

Hs.112278.0.S2_3p_at

Hs.112278.0.S2_3p_x_at

Hs.112278.2.A1_3p_at

Hs.22483.0.S1_3p_at

Hs.22483.0.S1_3p_s_at

ILMN_1730620

ILMN_1735218

ILMN_1819608

ILMN_1875302

ILMN_2325168

PH_hs_0006154

TC11002092.hg

g10880135_3p_a_at

Participant Of

input

output

hasCandidate

hasComponent

Activated PAR1:Beta-arrestin-1 [plasma membrane]

hasMember

ARRB [cytosol]

Other forms of this molecule

PolyUb-ARRB1 [cytosol]

ARRB1 [lysosomal membrane]

ARRB1 [Golgi membrane]

ARRB1 [cytoplasmic vesicle membrane]

Inferred To

arr-1 [cytosol] (Caenorhabditis elegans)

krz [cytosol] (Drosophila melanogaster)

Ghost homologue of ARRB1 [cytosol] (Gallus gallus)

arrb1 [cytosol] (Danio rerio)

arrb1 [cytosol] (Xenopus tropicalis)

ARRB1 [cytosol] (Canis familiaris)

ARRB1 [cytosol] (Sus scrofa)

Arrb1 [cytosol] (Mus musculus)

Arrb1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_064647.1, NP_004032.2

OpenTargets

ENSG00000137486

HPA

ENSG00000137486-ARRB1

GeneCards

P49407

Ensembl

ENST00000420843, ENSP00000353124, ENSP00000409581, ENSG00000137486, ENST00000360025

PRO

P49407

PDB

6PWC, 6UP7, 2IV8, 6TKO

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14749 GNMT	1	GNMT [cytosol] (R-HSA-5357674)	0.893	12
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.841	9
UniProt:O43298 ZBT43			0.742	5
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.669	8
UniProt:P20963 CD247			0.644	9
UniProt:O95218 ZRAB2			0.641	5
UniProt:Q14978 NOLC1			0.641	5
UniProt:Q13428 TCOF			0.641	4
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.641	3
UniProt:Q5JWF2 GNAS	1	GNAS1 [plasma membrane] (R-HSA-8873940)	0.639	5
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.623	3
UniProt:P53779 MAPK10	3	p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) MAPK10 [cytosol] (R-HSA-450352) p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311)	0.609	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.602	4
UniProt:P23528 CFL1	3	p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [cytosol] (R-HSA-350751) CFL1 [extracellular region] (R-HSA-350747)	0.577	3
UniProt:P36575 ARRC			0.564	3
UniProt:Q7Z4V5 HDGR2			0.564	3
UniProt:P63010-2 AP2B1			0.556	3
IntAct:EBI-22312375 CCSB ORF ID			0.556	3
UniProt:P14859-6 POU2F1			0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.547	2
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.544	3
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.527	4
UniProt:P50148 GNAQ	1	GNAQ [plasma membrane] (R-HSA-55453)	0.524	2
UniProt:Q7DB77 TIR			0.508	3
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.499	3
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.499	5
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.499	2
UniProt:P97288	1	Htr4 [plasma membrane] (R-MMU-391008)	0.499	5
UniProt:P62158 CALM			0.499	3
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.499	3
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.499	4
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.499	4
UniProt:O75688 PPM1B	1	PPM1B [cytosol] (R-HSA-1169375)	0.499	4
UniProt:P14618 PKM	3	PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387) PKM [secretory granule lumen] (R-HSA-6801401)	0.499	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.499	3
UniProt:Q15208 STK38			0.499	3
UniProt:P25101 EDNRA	1	EDNRA [plasma membrane] (R-HSA-388549)	0.499	3
UniProt:P06702 S100A9	3	S100A9 [cytosol] (R-HSA-9626869) S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [extracellular region] (R-HSA-5432857)	0.499	2
UniProt:Q00610 CLTC	6	CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [plasma membrane] (R-HSA-2980668) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820)	0.491	3
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) HN-HIF1A [cytosol] (R-HSA-1234110) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.463	3
UniProt:P25106 ACKR3	1	CXCR7 [plasma membrane] (R-HSA-373859)	0.463	2

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