Reactome | HSPA8 [cytosol]

HSPA8 [cytosol]

Stable Identifier

R-HSA-264476

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Heat shock cognate 71 kDa protein, HSP7C_HUMAN, HSC70

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Locations in the PathwayBrowser for interactor UniProt:Q9UPN7 PPP6R1

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External Reference Information

External Reference

UniProt:P11142 HSPA8

Gene Names

HSPA8, HSC70, HSP73, HSPA10

Chain

initiator methionine:1, chain:2-646

Reference Genes

BioGPS Gene:3312 HSPA8

COSMIC (genes):HSPA8 HSPA8

CTD Gene:3312 HSPA8

dbSNP Gene:3312 HSPA8

ENSEMBL:ENSG00000109971 HSPA8

HGNC:5241 HSPA8

KEGG Gene (Homo sapiens):3312 HSPA8

Monarch:3312 HSPA8

NCBI Gene:3312 HSPA8

OMIM:600816 HSPA8

UCSC:P11142 HSPA8

Reference Transcript

Other Identifiers

0001400131

0001400273

11720916_s_at

11741210_a_at

11741211_x_at

11756622_a_at

11762261_x_at

1179_at

1180_g_at

16745525

208687_x_at

210338_s_at

221891_x_at

224187_x_at

2989994

3011035

3312

33820_g_at

3395420

3395421

3395422

3395424

3395427

3395428

3395432

3395433

3395437

3395438

3395439

3395441

3395442

3395444

3395445

3395449

3395450

3395452

3395453

3395454

3395455

3401658

4020036

4020040

4020043

4020046

40637_at

44833_s_at

73372_r_at

7952325

A_23_P24594

A_24_P287129

A_24_P295745

A_32_P13728

A_33_P3390758

GE79248

GO:0000166

GO:0000398

GO:0000974

GO:0001664

GO:0001786

GO:0002376

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005776

GO:0005829

GO:0005886

GO:0005925

GO:0006397

GO:0006457

GO:0006605

GO:0006810

GO:0006914

GO:0006950

GO:0006986

GO:0007034

GO:0007049

GO:0007165

GO:0007267

GO:0007269

GO:0008088

GO:0008150

GO:0008289

GO:0008380

GO:0009056

GO:0009058

GO:0009267

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0016887

GO:0019221

GO:0019899

GO:0022607

GO:0023026

GO:0030424

GO:0030425

GO:0030674

GO:0030705

GO:0031072

GO:0031410

GO:0031625

GO:0031647

GO:0032991

GO:0034330

GO:0034620

GO:0034641

GO:0034655

GO:0034774

GO:0042026

GO:0042470

GO:0043167

GO:0043195

GO:0043202

GO:0043226

GO:0043254

GO:0043312

GO:0043488

GO:0044183

GO:0044403

GO:0044788

GO:0044829

GO:0045296

GO:0045892

GO:0046034

GO:0048026

GO:0048471

GO:0051082

GO:0051085

GO:0051087

GO:0051726

GO:0051787

GO:0055085

GO:0055131

GO:0061024

GO:0061077

GO:0061202

GO:0061635

GO:0061684

GO:0061738

GO:0061740

GO:0061741

GO:0065003

GO:0070062

GO:0072318

GO:0072562

GO:0098575

GO:0098684

GO:0098793

GO:0098978

GO:0099175

GO:0099523

GO:0099524

GO:0101031

GO:1900034

GO:1902904

GO:1904589

GO:1904764

GO:1904813

GO:1990832

GO:1990833

GO:1990904

Hs.180414.3.A1_3p_a_at

ILMN_1686367

ILMN_1716260

ILMN_2413084

PH_hs_0039202

PH_hs_0040139

TC11002390.hg

g11526572_3p_a_at

Participant Of

hasComponent

input

hasMember

output

Other forms of this molecule

Me3K561-HSPA8 [nucleoplasm]

HSPA8 [ficolin-1-rich granule lumen]

HSPA8 [extracellular region]

HSPA8 [secretory granule lumen]

HSPA8 [nucleoplasm]

HSPA8 [plasma membrane]

HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

HSPA8 [late endosome lumen]

HSPA8 [lysosomal lumen]

Inferred To

stag1 [cytosol] (Xenopus tropicalis)

hspE-2 [cytosol] (Dictyostelium discoideum)

hsp-1 [cytosol] (Caenorhabditis elegans)

hspB [cytosol] (Dictyostelium discoideum)

Hsc70-4 [cytosol] (Drosophila melanogaster)

hspa8b [cytosol] (Danio rerio)

HSPA8 [cytosol] (Canis familiaris)

HSPA8 [cytosol] (Dictyostelium discoideum)

HSPA8 [cytosol] (Gallus gallus)

HSPA8 [cytosol] (Plasmodium falciparum)

HSPA8 [cytosol] (Sus scrofa)

ssa2 [cytosol] (Schizosaccharomyces pombe)

SSA3 [cytosol] (Saccharomyces cerevisiae)

SSA4 [cytosol] (Saccharomyces cerevisiae)

ssa1 [cytosol] (Schizosaccharomyces pombe)

Homologues of HSPA8 [cytosol] (Dictyostelium discoideum)

Homologues of HSPA8 [cytosol] (Saccharomyces cerevisiae)

Homologues of HSPA8 [cytosol] (Schizosaccharomyces pombe)

Hspa8 [cytosol] (Mus musculus)

Hspa8 [cytosol] (Rattus norvegicus)

SSA1 [cytosol] (Saccharomyces cerevisiae)

SSA2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_006588.1, NP_694881.1, XP_011541100.1

OpenTargets

ENSG00000109971

ZINC - Substances

HSP7C_HUMAN

ZINC target

P11142

ZINC - Biogenic

HSP7C_HUMAN

PRO

P11142

PDB

5AQG, 6B1M, 6B1I, 5AQM, 5AQV, 3FZF, 5AQF, 5AQN, 4H5W, 5AQU, 3LDQ, 3FZK, 4HWI, 5AQI, 6B1N, 5AQO, 5AQH, 3FZH, 3M3Z, 5AQP, 3FZM, 4H5N, 3ESK, 5AQQ, 5AQJ, 4KBQ, 3FZL, 5AQR, 4H5V, 3AGZ, 3AGY, 4H5R, 5AQS, 5AQK, 5AQL, 4H5T, 5AQT

Target Pathogen

5b354852be737e166372e73a

ZINC - Metabolites

HSP7C_HUMAN

GeneCards

P11142

HPA

ENSG00000109971-HSPA8

Ensembl

ENST00000453788, ENST00000227378, ENSG00000109971, ENSP00000437125, ENSP00000404372, ENST00000532636, ENST00000534624, ENSP00000227378, ENSP00000432083

ZINC - Predictions - Purchasable

HSP7C_HUMAN

Orphanet

24608

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZL4 HPBP1			0.861	12
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.834	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.813	6
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.803	7
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.779	8
UniProt:P34932 HSPA4	2	HSPA4 [nucleoplasm] (R-HSA-5251998) HSPA4 [cytosol] (R-HSA-5251946)	0.734	6
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.719	13
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.718	6
UniProt:O14976 GAK	3	GAK [Golgi membrane] (R-HSA-434340) GAK [cytosol] (R-HSA-8868619) GAK [cytoplasmic vesicle membrane] (R-HSA-434203)	0.708	7
UniProt:O95429 BAG4	3	BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.666	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	14
UniProt:P54253 ATX1			0.666	13
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	8
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [cilium] (R-HSA-5617603) TRAF3IP1 [ciliary tip] (R-HSA-5625404)	0.664	5
UniProt:P00338 LDHA	1	LDHA [cytosol] (R-HSA-70502)	0.639	4
UniProt:P38260 FES1			0.61	4
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.597	3
UniProt:Q3B7T1 EDRF1			0.597	4
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.597	4
UniProt:Q99615 DNAJC7	2	DNAJC7 [nucleoplasm] (R-HSA-5255408) DNAJC7 [cytosol] (R-HSA-5252099)	0.597	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.597	4
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.597	8
UniProt:O75165 DNAJC13	3	DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [secretory granule membrane] (R-HSA-6800951) DNAJC13 [azurophil granule membrane] (R-HSA-6799140)	0.597	4
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.573	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.564	2
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.564	2
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:Q9BQI3 EIF2AK1	2	p-T,T486,T488-EIF2AK1 [cytosol] (R-HSA-9648894) p-T-EIF2AK1 [cytosol] (R-HSA-9648892)	0.564	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P01308-PRO_0000015820 INS			0.558	2
UniProt:P10636-6 MAPT			0.558	3
UniProt:P01893 HLA-H	8	HLA-H [phagocytic vesicle membrane] (R-HSA-8855901) HLA-H [azurophil granule membrane] (R-HSA-6799339) HLA-H [recycling endosome membrane] (R-HSA-8863855) HLA-H [early endosome membrane] (R-HSA-8855898) HLA-H [ER to Golgi transport vesicle membrane] (R-HSA-8855892) HLA-H [plasma membrane] (R-HSA-6806266) HLA-H [Golgi membrane] (R-HSA-8855895) HLA-H [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-8855907)	0.558	2
UniProt:P10636 MAPT	3	MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642) MAPT [cytosol] (R-HSA-201574)	0.558	5
UniProt:O60260-5 PRKN			0.556	9
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.547	2
UniProt:P36507 MAP2K2	12	MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089)	0.527	3
UniProt:Q38SD2 LRRK1			0.527	2
UniProt:Q13620 CUL4B	2	G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522) CUL4B [nucleoplasm] (R-HSA-975973)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:Q9NVT9 ARMC1			0.527	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.527	2
UniProt:P63092 GNAS	1	GNAS2 [plasma membrane] (R-HSA-164387)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF [cytosol] (R-HSA-167224) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.527	2
UniProt:P03485 M	6	M1 [extracellular region] (R-FLU-169241) M1 [plasma membrane] (R-FLU-195782) M1 [endocytic vesicle membrane] (R-FLU-189168) M1 [endosome lumen] (R-FLU-189155) M1 [nucleoplasm] (R-FLU-186959) M1 [cytosol] (R-FLU-169073)	0.524	4
UniProt:Q9NQ11 ATP13A2	1	ATP13A2 [lysosomal lumen] (R-HSA-939762)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	3
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.499	2
UniProt:Q9GZX7 AICDA			0.499	2
UniProt:P14598 NCF1	4	p-6S-NCF1 [phagolysosome] (R-HSA-1996220) NCF1 [cytosol] (R-HSA-1222296) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.499	2
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.499	4
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.499	2
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4
UniProt:Q99IB8-PRO_0000045599			0.488	2
UniProt:O75190 DNAJB6	2	DNAJB6 [nucleoplasm] (R-HSA-5255425) DNAJB6 [cytosol] (R-HSA-5252014)	0.482	2
UniProt:O95801 TTC4			0.482	2
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.462	3
UniProt:O14654 IRS4	2	IRS4 [plasma membrane] (R-HSA-2424297) p-Y-IRS4 [plasma membrane] (R-HSA-2424302)	0.462	2
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.462	4
UniProt:O94927 HAUS5	1	HAUS5 [cytosol] (R-HSA-8855197)	0.462	3
UniProt:Q9BQC3 DPH2	1	DPH2 [cytosol] (R-HSA-5358368)	0.462	3
UniProt:P09496 CLTA	6	CLTA [trans-Golgi network membrane] (R-HSA-5333758) CLTA [cytosol] (R-HSA-8856817) CLTA [plasma membrane] (R-HSA-2980611) CLTA [clathrin-coated endocytic vesicle membrane] (R-HSA-5138427) CLTA [endolysosome membrane] (R-HSA-8870825) CLTA [lysosomal membrane] (R-HSA-2980595)	0.462	3
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.462	2
UniProt:Q9UBB4 ATX10			0.462	3
UniProt:Q9NNW5 WDR6			0.462	3
UniProt:Q9UNF1 MAGED2	2	MAGED2 [platelet alpha granule lumen] (R-HSA-8862956) MAGED2 [extracellular region] (R-HSA-8862948)	0.462	3
UniProt:Q9UPN7 PPP6R1	1	PPP6R1 [cytosol] (R-HSA-5685721)	0.462	2
UniProt:Q15773 MLF2			0.462	4
UniProt:Q9BWH6 RPAP1			0.462	2
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.462	3
UniProt:Q9BZG8 DPH1	1	DPH1 [cytosol] (R-HSA-5358384)	0.462	3
UniProt:Q92598 HSPH1	3	HSPH1 [extracellular region] (R-HSA-3221883) HSPH1 [endocytic vesicle lumen] (R-HSA-3221904) HSPH1 [cytosol] (R-HSA-3299412)	0.462	3
UniProt:Q00610 CLTC	6	CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [plasma membrane] (R-HSA-2980668) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820)	0.462	4
UniProt:O95757 HSPA4L	2	HSPA4L [nucleoplasm] (R-HSA-5252053) HSPA4L [cytosol] (R-HSA-5251943)	0.462	3
UniProt:P08243 ASNS	1	ASNS [cytosol] (R-HSA-70597)	0.462	2

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