Loading of acetylcholine in synaptic vesicles

Stable Identifier
R-HSA-264615
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Acetylcholine is actively transported from the cytosol to the lumen of the synaptic vesicle by vesicular acetylcholine transporter. Two protons are exchanged for 1 molecule of acetylcholine. The vesicular acetylcholine transporter is located in the membrane of the synaptic vesicle.
Literature References
PubMed ID Title Journal Year
8071310 Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus

Eiden, LE, Diebler, MF, Varoqui, H, Weihe, E, Usdin, TB, Erickson, JD, Modi, W, Rand, J, Bonner, TI, Schäfer, MK

J Biol Chem 1994
Participants
Participates
Catalyst Activity

acetylcholine transmembrane transporter activity of SLC18A3 [clathrin-sculpted acetylcholine transport vesicle membrane]

Orthologous Events
Authored
Cite Us!