Caspase-mediated cleavage of cytoskeletal proteins

Stable Identifier
R-HSA-264870
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Caspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and plectin) may directly contribute to apoptotic changes in cell shape.

Literature References
PubMed ID Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates

Fischer, U, Janicke, RU, Schulze-Osthoff, K

Cell Death Differ 2003
17254298 SVM-based prediction of caspase substrate cleavage sites

Wee, LJ, Tan, TW, Ranganathan, S

BMC Bioinformatics 2006
17599937 CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

Wee, LJ, Tan, TW, Ranganathan, S

Bioinformatics 2007
Participants
Participant Of
Orthologous Events
Cross References
Authored
Reviewed
Created