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EXOC4 [plasma membrane]
Stable Identifier
R-HSA-264989
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser for interactor UniProt:Q9UJY5 GGA1
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Insulin processing (Homo sapiens)
Exocyst complex formation (Homo sapiens)
EXOC4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96A65 EXOC4
Gene Names
EXOC4, KIAA1699, SEC8, SEC8L1
Chain
initiator methionine:, chain:2-974
Reference Genes
BioGPS Gene:60412 EXOC4
COSMIC (genes):EXOC4 EXOC4
CTD Gene:60412 EXOC4
dbSNP Gene:60412 EXOC4
ENSEMBL:ENSG00000131558 EXOC4
ENSEMBL_homo_sapiens_GENE:ENSG00000131558.15 EXOC4
HGNC:30389 EXOC4
KEGG Gene (Homo sapiens):60412 EXOC4
Monarch:60412 EXOC4
NCBI Gene:60412 EXOC4
OMIM:608185 EXOC4
UCSC:Q96A65 EXOC4
Reference Transcript
RefSeq:NM_021807.3 EXOC4
Other Identifiers
11718791_s_at
11718792_a_at
11733715_a_at
11733716_x_at
17051745
224926_PM_at
224926_at
240528_3p_s_at
240528_PM_s_at
240528_s_at
3025006
3025007
3025011
3025012
3025017
3025024
3025025
3025028
3025029
3025030
3025056
3025057
3025061
3025062
3025090
3025127
3025128
3025137
3025138
3025151
3025154
3025155
3025176
3025177
3025178
3025179
3025212
3025213
3025214
3025215
3025216
3025217
3025218
48072_at
48073_g_at
60412
72841_at
8136293
91389_at
A_14_P111352
A_14_P124224
A_14_P202004
A_24_P7946
GE62357
GO:0000145
GO:0000278
GO:0000281
GO:0000910
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005902
GO:0006887
GO:0006893
GO:0006904
GO:0006914
GO:0007268
GO:0015031
GO:0016020
GO:0016192
GO:0016241
GO:0023052
GO:0030165
GO:0032584
GO:0035748
GO:0042995
GO:0043005
GO:0043226
GO:0045202
GO:0048341
GO:0048856
GO:0061024
GO:0090148
GO:0090522
GO:0090543
HMNXSV003046686
HMNXSV003058107
Hs.107394.0.S1_3p_at
Hs.223829.0.A1_3p_at
Hs.223829.0.A1_3p_s_at
ILMN_1742827
ILMN_2394750
PH_hs_0026072
Participates
as a component of
Exocyst Complex [plasma membrane] (Homo sapiens)
as an input of
Exocyst complex formation (Homo sapiens)
Other forms of this molecule
EXOC4 [cytosol]
Inferred To
Sec8 [plasma membrane]
(Drosophila melanogaster)
exoc4 [plasma membrane]
(Dictyostelium discoideum)
exoc4 [plasma membrane]
(Xenopus tropicalis)
EXOC4 [plasma membrane]
(Bos taurus)
EXOC4 [plasma membrane]
(Canis familiaris)
EXOC4 [plasma membrane]
(Gallus gallus)
Exoc4 [plasma membrane]
(Mus musculus)
Exoc4 [plasma membrane]
(Rattus norvegicus)
SEC8 [plasma membrane]
(Saccharomyces cerevisiae)
sec-8 [plasma membrane]
(Caenorhabditis elegans)
sec8 [plasma membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_068579.3
OpenTargets
ENSG00000131558
GeneCards
Q96A65
HPA
ENSG00000131558-EXOC4
Ensembl
ENST00000393161
,
ENSG00000131558
,
ENSP00000376868
,
ENST00000253861
,
ENSP00000253861
PRO
Q96A65
Pharos - Targets
Q96A65
PDB
7PC5
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.852
7
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.789
7
UniProt:Q8IYI6 EXOC8
2
EXOC8 [plasma membrane]
(R-HSA-264948)
EXOC8 [cytosol]
(R-HSA-5623388)
0.789
8
UniProt:O60645 EXOC3
2
EXOC3 [secretory granule membrane]
(R-HSA-2872286)
EXOC3 [cytosol]
(R-HSA-5623379)
0.725
6
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.725
5
UniProt:Q9Y2D4 EXC6B
0.638
5
UniProt:Q9UPT5 EXOC7
2
EXOC7 [plasma membrane]
(R-HSA-2872288)
EXOC7 [cytosol]
(R-HSA-5623386)
0.638
4
UniProt:Q9H5N1 RABE2
0.638
3
UniProt:Q96KP1 EXOC2
2
EXOC2 [plasma membrane]
(R-HSA-264887)
EXOC2 [cytosol]
(R-HSA-5623376)
0.638
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
6
UniProt:O70172
2
Pip4k2a [nucleoplasm]
(R-MMU-6811484)
Pip4k2a [cytosol]
(R-MMU-1604641)
0.558
3
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.556
3
UniProt:Q9NR09 BIRC6
2
BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713451)
BIRC6(1-958)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713450)
0.556
3
UniProt:Q96EV8 DTNBP1
1
DTNBP1 [cytosol]
(R-HSA-429819)
0.547
2
UniProt:P27930 IL1R2
1
IL1R2 [plasma membrane]
(R-HSA-197598)
0.527
4
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.527
2
UniProt:O75558 STX11
0.527
2
UniProt:Q9UJY5 GGA1
2
GGA1 [early endosome membrane]
(R-HSA-8854136)
GGA1 [endosome membrane]
(R-HSA-5692930)
0.527
3
UniProt:Q86VI4 LAP4B
0.524
2
UniProt:Q53HC9 EIPR1
0.508
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.508
3
UniProt:Q9UID3 VPS51
1
VPS51 [trans-Golgi network membrane]
(R-HSA-6811027)
0.508
2
UniProt:Q15051 IQCB1
1
IQCB1 [cytosol]
(R-HSA-5626648)
0.508
2
UniProt:Q15276 RABEP1
1
RABEP1 [early endosome membrane]
(R-HSA-2029004)
0.508
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.499
2
UniProt:P04601 nef
3
nef [cytosol]
(R-HIV-165575)
myristoylated Nef Protein (UniProt:P04601) [extracellular region]
(R-HIV-3597665)
myristoylated nef [cytosol]
(R-HIV-167605)
0.462
2
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