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RPN1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-264994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Spike protein gets N-glycosylated (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
RPN1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transfer of N-glycan to the protein (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
RPN1 [endoplasmic reticulum membrane] (Homo sapiens)
Translation (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
cleaved polypeptide:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
Translocon:TRAP [endoplasmic reticulum membrane] (Homo sapiens)
RPN1 [endoplasmic reticulum membrane] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
Translocon:TRAP [endoplasmic reticulum membrane] (Homo sapiens)
RPN1 [endoplasmic reticulum membrane] (Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
Translocon:TRAP [endoplasmic reticulum membrane] (Homo sapiens)
RPN1 [endoplasmic reticulum membrane] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
Translocon:TRAP [endoplasmic reticulum membrane] (Homo sapiens)
RPN1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04843 RPN1
Gene Names
RPN1
Chain
signal peptide:1-23, chain:24-607
Reference Genes
BioGPS Gene:6184 RPN1
COSMIC (genes):RPN1 RPN1
CTD Gene:6184 RPN1
dbSNP Gene:6184 RPN1
ENSEMBL:ENSG00000163902 RPN1
HGNC:10381 RPN1
KEGG:hsa:6184 RPN1
Monarch:6184 RPN1
NCBI Gene:6184 RPN1
OMIM:180470 RPN1
UCSC:P04843 RPN1
Reference Transcript
RefSeq:NM_002950.3 RPN1
Other Identifiers
11742852_a_at
11742853_x_at
11748113_a_at
11749429_a_at
16958864
201011_PM_at
201011_at
230862_PM_at
230862_at
2694398
2694399
2694400
2694401
2694403
2694404
2694405
2694407
2694408
2694409
2694410
2694411
2694412
2694414
2694415
2694418
2694419
2694420
2694421
2694437
33424_at
6184
8090490
A_23_P132809
A_23_P254340
A_24_P63262
A_32_P48536
GE58292
GO:0003723
GO:0003824
GO:0004579
GO:0005515
GO:0005783
GO:0005789
GO:0005791
GO:0005829
GO:0006486
GO:0006487
GO:0008250
GO:0016020
GO:0016740
GO:0018279
GO:0031410
GO:0042470
GO:0043226
HMNXSV003047593
Hs.250112.0.A1_3p_at
ILMN_1660533
TC03001757.hg
Y00281_at
g4506674_3p_at
Participates
as a component of
Translocon:TRAP [endoplasmic reticulum membrane] (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
Cross References
RefSeq
NP_002941.1
ENSEMBL
ENST00000296255
,
ENSP00000296255
OpenTargets
ENSG00000163902
HPA
ENSG00000163902-RPN1
PRO
P04843
Pharos - Targets
P04843
GlyGen
P04843
Orphanet
RPN1
HMDB Protein
HMDBP01589
PDB
6S7T
,
6S7O
,
8B6L
,
8PN9
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.706
22
UniProt:Q14165 MLEC
3
MLEC [endoplasmic reticulum membrane]
(R-HSA-901082)
MLEC [plasma membrane]
(R-HSA-6806292)
MLEC [specific granule membrane]
(R-HSA-6799618)
0.688
3
UniProt:Q8TCJ2 STT3B
1
STT3B [endoplasmic reticulum membrane]
(R-HSA-264930)
0.688
4
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.569
4
UniProt:O00213 APBB1
1
APBB1 [nucleoplasm]
(R-HSA-5683987)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.499
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.483
2
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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