Reactome | SRPRB [endoplasmic reticulum membrane]

SRPRB [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-265002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SRP Receptor subunit beta

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y5M8 SRPRB

Gene Names

SRPRB, PSEC0230

Chain

chain:1-271

Reference Genes

BioGPS Gene:58477 SRPRB

COSMIC (genes):SRPRB SRPRB

CTD Gene:58477 SRPRB

dbSNP Gene:58477 SRPRB

ENSEMBL:ENSG00000144867 SRPRB

HGNC:24085 SRPRB

KEGG:hsa:58477 SRPRB

Monarch:58477 SRPRB

NCBI Gene:58477 SRPRB

OMIM:616883 SRPRB

UCSC:Q9Y5M8 SRPRB

Reference Transcript

Other Identifiers

11717377_s_at

11717378_at

11758775_at

16945907

218140_PM_x_at

218140_x_at

222532_PM_at

222532_at

227737_PM_at

227737_at

2643285

2643286

2643325

2643326

2643327

2643329

2643330

2643331

2643332

2643333

2643334

2643337

2643338

2643339

2643341

56529_at

58477

76809_at

8082816

A_14_P107072

A_14_P127462

A_23_P80773

GE61776

GO:0005525

GO:0005737

GO:0005783

GO:0005785

GO:0005789

GO:0005881

GO:0006617

GO:0016020

GO:0043226

GO:0045047

GO:0065003

HMNXSV003015822

Hs.12152.0.S1_3p_at

Hs.12152.1.S1_3p_at

ILMN_1751072

PH_hs_0001146

TC03000725.hg

g10864014_3p_a_at

Participates

as an output of

Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)

as a component of

SRP receptor [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

RefSeq

NP_067026.3, NP_001366242.1

OpenTargets

ENSG00000144867

ENSEMBL

ENSP00000503923, ENSG00000144867, ENST00000678299, ENSP00000418401, ENST00000466490

HPA

ENSG00000144867-SRPRB

GeneCards

SRPRB

PRO

Q9Y5M8

Pharos - Targets

Q9Y5M8

GlyGen

Q9Y5M8

PDB

7NFX

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08240 SRPRA	1	SRPR [endoplasmic reticulum membrane] (R-HSA-264970)	0.788	6
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.725	5
UniProt:Q96JB5 CK5P3			0.659	3
UniProt:Q9UNK0 STX8			0.643	3
UniProt:Q8WUY1 THEM6			0.643	4
UniProt:Q6PCB8 EMB	1	EMB [plasma membrane] (R-HSA-8856535)	0.643	3
UniProt:P09601 HMOX1	4	HMOX1 [cytosol] (R-HSA-9609901) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [nucleoplasm] (R-HSA-9708567)	0.643	3
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.569	4
UniProt:Q9Y6B6 SAR1B	3	SAR1B [endoplasmic reticulum membrane] (R-HSA-203995) SAR1B [ER to Golgi transport vesicle membrane] (R-HSA-211498) SAR1B [cytosol] (R-HSA-174678)	0.527	2
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.527	2
UniProt:Q13049 TRIM32	1	TRIM32 [cytosol] (R-HSA-976030)	0.527	2
UniProt:Q9Y394 DHRS7			0.527	3
UniProt:Q86VZ4 LRP11			0.527	2
UniProt:P84085 ARF5	1	ARF5 [cytosol] (R-HSA-6807737)	0.527	2
UniProt:O95476 CTDNEP1	1	CTDNEP1 [nuclear envelope] (R-HSA-3632863)	0.527	2
UniProt:Q8NEN9 PDZD8			0.527	3
UniProt:P61006 RAB8A	6	RAB8A [Golgi membrane] (R-HSA-2562535) RAB8A [cytosol] (R-HSA-5623399) GGC-RAB8A [cytosol] (R-HSA-8874063) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093)	0.527	2
UniProt:Q9NVJ2 ARL8B			0.527	2
UniProt:Q9H6Y7 RN167			0.527	2
UniProt:Q96KC2 ARL5B			0.527	3
UniProt:P40425 PBX2			0.527	2
UniProt:Q9Y263 PLAP			0.527	2
UniProt:Q4ZIN3 MBRL			0.527	2
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.527	2
UniProt:Q7Z4R8 C6orf120	2	C6ORF120 [extracellular region] (R-HSA-6806197) C6ORF120 [azurophil granule lumen] (R-HSA-6799358)	0.527	2
UniProt:Q99614 TTC1			0.527	2
UniProt:P07099 EPHX1	1	EPHX1 [endoplasmic reticulum membrane] (R-HSA-5694132)	0.527	2
UniProt:Q9NWS8 RMND1			0.527	2
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.527	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.483	2

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