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STT3A [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-265023
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Dengue Virus Infection (Homo sapiens)
Dengue Virus Genome Translation and Replication (Homo sapiens)
Maturation of DENV proteins (Homo sapiens)
E is N-glycosylated (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
Pre-NS1 folds and is N-glycosylated (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
pre-M is N-glycosylated (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Spike protein gets N-glycosylated (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Regulation of PD-L1(CD274) expression (Homo sapiens)
Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
CD274 N-linked glycosylation in ER (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transfer of N-glycan to the protein (Homo sapiens)
OST complex [endoplasmic reticulum membrane] (Homo sapiens)
OST-A [endoplasmic reticulum membrane] (Homo sapiens)
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
STT3A [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46977 STT3A
Gene Names
STT3A, ITM1, TMC
Chain
chain:1-705
Reference Genes
BioGPS Gene:3703 STT3A
COSMIC (genes):STT3A STT3A
CTD Gene:3703 STT3A
dbSNP Gene:3703 STT3A
ENSEMBL:ENSG00000134910 STT3A
HGNC:6172 STT3A
KEGG:hsa:3703 STT3A
Monarch:3703 STT3A
NCBI Gene:3703 STT3A
OMIM:601134 STT3A
UCSC:P46977 STT3A
Reference Transcript
RefSeq:NM_001278503.2 STT3A
RefSeq:XM_054368692.1 STT3A
RefSeq:NM_001278504.2 STT3A
RefSeq:XM_047426896.1 STT3A
RefSeq:NM_152713.5 STT3A
RefSeq:XM_047426897.1 STT3A
RefSeq:XM_047426895.1 STT3A
RefSeq:XM_011542807.4 STT3A
RefSeq:XM_054368693.1 STT3A
RefSeq:XM_054368694.1 STT3A
Other Identifiers
11725944_a_at
16733070
202223_PM_at
202223_at
3354763
3354765
3354766
3354767
3354768
3354769
3354770
3354771
3354772
3354773
3354774
3354775
3354776
3354777
3354778
3354779
3354780
3354781
3354782
3354783
3354784
3354785
3354786
3354787
3354790
3354791
3354792
3354793
3354794
3354795
3354796
3354798
3354800
3354801
3354802
3354803
3354804
3703
37991_at
7944991
A_14_P135494
A_23_P104734
GE57754
GE849767
GO:0004576
GO:0004579
GO:0005515
GO:0005783
GO:0005789
GO:0006486
GO:0006487
GO:0008250
GO:0016020
GO:0016740
GO:0016757
GO:0018279
GO:0043686
GO:0043687
GO:0046872
GO:0160226
HMNXSV003057785
ILMN_1746090
L38961_at
PH_hs_0014923
TC11003469.hg
g4504786_3p_at
Participates
as a component of
OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
STT3A [endoplasmic reticulum membrane]
(Bos taurus)
STT3A [endoplasmic reticulum membrane]
(Canis familiaris)
STT3A [endoplasmic reticulum membrane]
(Gallus gallus)
STT3A [endoplasmic reticulum membrane]
(Sus scrofa)
stt3a [endoplasmic reticulum membrane]
(Danio rerio)
stt3a [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Ghost homologue of STT3A [endoplasmic reticulum membrane]
(Rattus norvegicus)
Stt3a [endoplasmic reticulum membrane]
(Mus musculus)
Cross References
RefSeq
XP_054224668.1
,
XP_054224667.1
,
XP_047282852.1
,
XP_011541109.1
,
XP_047282853.1
,
XP_047282851.1
,
NP_001265432.1
,
NP_001265433.1
,
NP_689926.1
,
XP_054224669.1
OpenTargets
ENSG00000134910
ENSEMBL
ENSP00000432820
,
ENSP00000376472
,
ENST00000531491
,
ENST00000392708
,
ENST00000649491
,
ENSP00000497336
,
ENST00000529196
,
ENSG00000134910
,
ENSP00000436962
IntEnz
2.4.99.18
HPA
ENSG00000134910-STT3A
GeneCards
STT3A
PRO
P46977
Pharos - Targets
P46977
Orphanet
STT3A
GlyGen
P46977
PDB
8PN9
,
8B6L
,
6S7O
HMDB Protein
HMDBP02781
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.615
12
UniProt:P27824 CANX
3
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum membrane]
(R-HSA-9932989)
0.569
3
UniProt:P16284 PECAM1
5
PECAM1 [plasma membrane]
(R-HSA-114686)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
0.556
3
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q86WV6 STING1
7
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
STING(1-95) [cytosol]
(R-HSA-3244586)
STING(96-379) [cytosol]
(R-HSA-3244622)
0.499
2
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.499
2
UniProt:Q6PDS3
1
Sarm1 [cytosol]
(R-MMU-2559572)
0.499
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.499
2
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