Reactome | STT3A [endoplasmic reticulum membrane]

STT3A [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-265023

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        STT3A [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transfer of N-glycan to the protein (Homo sapiens)
      - OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        STT3A [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46977 STT3A

Gene Names

STT3A, ITM1, TMC

Chain

chain:1-705

Reference Genes

BioGPS Gene:3703 STT3A

COSMIC (genes):STT3A STT3A

CTD Gene:3703 STT3A

dbSNP Gene:3703 STT3A

ENSEMBL:ENSG00000134910 STT3A

HGNC:6172 STT3A

KEGG:hsa:3703 STT3A

Monarch:3703 STT3A

NCBI Gene:3703 STT3A

OMIM:601134 STT3A

UCSC:P46977 STT3A

Reference Transcript

Other Identifiers

11725944_a_at

16733070

202223_PM_at

202223_at

3354763

3354765

3354766

3354767

3354768

3354769

3354770

3354771

3354772

3354773

3354774

3354775

3354776

3354777

3354778

3354779

3354780

3354781

3354782

3354783

3354784

3354785

3354786

3354787

3354790

3354791

3354792

3354793

3354794

3354795

3354796

3354798

3354800

3354801

3354802

3354803

3354804

3703

37991_at

7944991

A_14_P135494

A_23_P104734

GE57754

GE849767

GO:0003824

GO:0004576

GO:0004579

GO:0005515

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0016740

GO:0016757

GO:0018279

GO:0035000

GO:0043226

GO:0043686

GO:0043687

GO:0046872

HMNXSV003057785

ILMN_1746090

L38961_at

PH_hs_0014923

TC11003469.hg

g4504786_3p_at

Participates

as a component of

OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

RefSeq

XP_011541109.1, NP_001265432.1, NP_689926.1, NP_001265433.1

OpenTargets

ENSG00000134910

ENSEMBL

ENSP00000497336, ENSG00000134910, ENSP00000436962, ENST00000649491, ENST00000531491, ENST00000529196, ENSP00000376472, ENST00000392708, ENSP00000432820

IntEnz

2.4.99.18

HPA

ENSG00000134910-STT3A

GeneCards

STT3A

PRO

P46977

Pharos - Targets

P46977

Orphanet

STT3A

GlyGen

P46977

PDB

8PN9, 8B6L, 6S7O

HMDB Protein

HMDBP02781

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	12
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.499	2
UniProt:Q6PDS3	1	SARM-1 [cytosol] (R-MMU-2559572)	0.499	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.499	2
UniProt:Q86WV6 STING1	5	STING [endoplasmic reticulum membrane] (R-HSA-1834940) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815)	0.499	2

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