Prostaglandin E synthase isomerizes PGH2 to PGE2

Stable Identifier
R-HSA-265295
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Prostaglandin E2 (PGE2) is the most abundant prostanoid in the body and is a major mediator of inflammation in diseases such as osteoarthritis and rheumatoid arthritis. The product of arachidonic acid, prostaglandin H2 (PGH2) serves as the substrate for the isomerization to PGE2. The conversion is carried out by prostaglandin E synthases. Of the three forms, two are predominanly cytosolic. Prostaglandin E synthase 3 (PTGES3) is also called cytosolic prostaglandin E2 synthase (cPGES). Prostaglandin E synthase 2 (mPGES-2, PTGES2) is synthesized as a Golgi membrane-associated protein which undergoes a spontaneous cleavage of the N-terminal hydrophobic domain leading to a truncated mature cytosolic protein.

Literature References
PubMed ID Title Journal Year
12835322 Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2

Murakami, M, Nakashima, K, Kamei, D, Masuda, S, Ishikawa, Y, Ishii, T, Ohmiya, Y, Watanabe, K, Kudo, I

J. Biol. Chem. 2003
10922363 Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis

Tanioka, T, Nakatani, Y, Semmyo, N, Murakami, M, Kudo, I

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
prostaglandin-E synthase activity of PTGES2(88-377), PTGES3 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed