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Arachidonic acid is oxidised to 5S-HpETE by ALOX5

Stable Identifier
R-HSA-265296
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Oxidation of arachidonic acid to 5-HpETE
Locations in the PathwayBrowser
Summation

Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid in a two-step process. First, arachidonic acid AA is oxidized to form 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 5-lipoxygenase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea