Reactome | Arachidonic acid is oxidised to 5S-HpETE by ALOX5

Arachidonic acid is oxidised to 5S-HpETE by ALOX5

Stable Identifier

R-HSA-265296

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

Synonyms

Oxidation of arachidonic acid to 5-HpETE

ReviewStatus

5/5

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Arachidonic acid is oxidised to 5S-HpETE by ALOX5

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Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid in a two-step process. First, arachidonic acid AA is oxidized to form 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3118366	Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase Rouzer, CA, Samuelsson, B	Proc Natl Acad Sci U S A	1987
3006030	Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities Matsumoto, T, Rouzer, CA, Samuelsson, B	Proc Natl Acad Sci U S A	1986
3164719	Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells Register, RB, Jones, RE, Kargman, S, Dixon, RA, Rouzer, CA, Rands, E	J Biol Chem	1988