Corticotropin cleavage from POMC

Stable Identifier
R-HSA-265301
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Corticotropin (adrenocorticotropic hormone, ACTH) is a 39-amino acid polypeptide hormone produced and secreted by the pituitary gland. It is often produced in response to biological stress (along with corticotropin-releasing hormone). Its principal effects are increased production of androgens and cortisol. Corticotropin is processed from the precursor pro-opiomelanocortin (POMC). The enzyme that performs the cleavage of POMC to corticotropin is prohormone convertase 1 (PC1). In addition to corticotropin, POMC is processed into other small, biologically active fragments. These include lipotropins, melanocyte-stimulating hormone and endorphins.

Literature References
PubMed ID Title Journal Year
9207799 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

Jackson, RS, Creemers, JW, Ohagi, S, Raffin-Sanson, ML, Sanders, L, Montague, CT, Hutton, JC, O'Rahilly, S

Nat Genet 1997
14463577 On the structure of human corticotropin (adrenocorticotropic hormone)

Lee, TH, Lerner, AB, Buettner-Janusch, V

J Biol Chem 1961
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
Physical Entity
Activity
Orthologous Events
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