Interaction of integrin alphaEbeta7 with Cadherin-1

Stable Identifier
R-HSA-265422
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

E-cadherin, memeber of the cadherin superfamily is a calcium-dependent cell adhesion protein expressed on the epithelial cells. The integrin alphaEbeta7 is selectively expressed on intestinal intraepithelial T lymphocytes and CD8+ T lymphocytes in inflammatory lesions near epithelial cells. E-cadherin undergoes both homophilic and heterophilic interactions. It is the only binding partner for alphaEbeta7. This interaction plays a key role in the proliferation of intrathymic T cell populations, T lymphocyte development and damage of target epithelia.

Literature References
PubMed ID Title Journal Year
16002701 Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion

Shiraishi, K, Tsuzaka, K, Yoshimoto, K, Kumazawa, C, Nozaki, K, Abe, T, Tsubota, K, Takeuchi, T

J Immunol 2005
15330449 Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus

Prockop, SE, Petrie, HT

Clin Dev Immunol 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed