Reactome | Interaction of integrin alphaEbeta7 with Cadherin-1

Interaction of integrin alphaEbeta7 with Cadherin-1

Stable Identifier

R-HSA-265422

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Interaction of integrin alphaEbeta7 with Cadherin-1

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E-cadherin, memeber of the cadherin superfamily is a calcium-dependent cell adhesion protein expressed on the epithelial cells. The integrin alphaEbeta7 is selectively expressed on intestinal intraepithelial T lymphocytes and CD8+ T lymphocytes in inflammatory lesions near epithelial cells. E-cadherin undergoes both homophilic and heterophilic interactions. It is the only binding partner for alphaEbeta7. This interaction plays a key role in the proliferation of intrathymic T cell populations, T lymphocyte development and damage of target epithelia.

Literature References

PubMed ID	Title	Journal	Year
15330449	Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus Prockop, SE, Petrie, HT	Clin Dev Immunol	2004
16002701	Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion Shiraishi, K, Tsuzaka, K, Yoshimoto, K, Kumazawa, C, Nozaki, K, Abe, T, Tsubota, K, Takeuchi, T	J Immunol	2005