Interaction of integrin alphaVbeta3 with Fibrillin

Stable Identifier
R-HSA-265423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Fibrillins are the main constituents of the extracellular microfibrils that form a template for tropoelastin during elastic fibrillogenesis. Fibrillins polymerize extracellularly as parallel bundles of head-to-tail monomers. The integrin receptor alphaVbeta3 is the major receptor for the fibrillin ligands and influences cell shape and migration, focal complex formation, signaling and ECM deposition.

Literature References
PubMed ID Title Journal Year
12807887 Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins

Bax, DV, Bernard, SE, Lomas, A, Morgan, A, Humphries, J, Shuttleworth, CA, Humphries, MJ, Kielty, CM

J Biol Chem 2003
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Orthologous Events
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